{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:02Z","timestamp":1791214502317,"version":"4.1.0"},"reference-count":52,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:p> Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25[OH]D correlates with functional recovery of skeletal muscle following eccentric contractions in humans and crush injury in rats. However, a definitive association is yet to be established. To address this gap in knowledge in relation to damage repair, a randomised, placebo-controlled trial was performed in 20 males with insufficient concentrations of serum 25(OH)D (45 \u00b1 25 nmol\/l). Prior to and following 6 wk of supplemental vitamin D<jats:sub>3<\/jats:sub> (4,000 IU\/day) or placebo (50 mg of cellulose), participants performed 20 \u00d7 10 damaging eccentric contractions of the knee extensors, with peak torque measured over the following 7 days of recovery. Parallel experimentation using isolated human skeletal muscle-derived myoblast cells from biopsies of 14 males with low serum 25(OH)D (37 \u00b1 11 nmol\/l) were subjected to mechanical wound injury, which enabled corresponding in vitro studies of muscle repair, regeneration, and hypertrophy in the presence and absence of 10 or 100 nmol 1\u03b1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3.<\/jats:sub> Supplemental vitamin D<jats:sub>3<\/jats:sub> increased serum 25(OH)D and improved recovery of peak torque at 48 h and 7 days postexercise. In vitro, 10 nmol 1\u03b1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> improved muscle cell migration dynamics and resulted in improved myotube fusion\/differentiation at the biochemical, morphological, and molecular level together with increased myotube hypertrophy at 7 and 10 days postdamage. Together, these preliminary data are the first to characterize a role for vitamin D in human skeletal muscle regeneration and suggest that maintaining serum 25(OH)D may be beneficial for enhancing reparative processes and potentially for facilitating subsequent hypertrophy. <\/jats:p>","DOI":"10.1152\/ajpendo.00375.2015","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T23:28:19Z","timestamp":1445988499000},"page":"E1019-E1031","source":"Crossref","is-referenced-by-count":122,"title":["A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy"],"prefix":"10.1152","volume":"309","author":[{"given":"Daniel J.","family":"Owens","sequence":"first","affiliation":[{"name":"Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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