{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:38:40Z","timestamp":1789810720151,"version":"4.0.1"},"reference-count":51,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Decreased dietary protein intake and hemodialysis (HD)-associated protein catabolism are among several factors that predispose chronic hemodialysis (CHD) patients to uremic malnutrition and associated muscle wasting. Intradialytic parenteral nutrition (IDPN) acutely reverses the net negative whole body and forearm muscle protein balances observed during the HD procedure. Exercise has been shown to improve muscle protein homeostasis, especially if performed with adequately available intramuscular amino acids. We hypothesized that exercise performance would provide additive anabolic effects to the beneficial effects of IDPN. We studied six CHD patients at two separate HD sessions: 1) IDPN administration only and 2) IDPN + exercise. Patients were studied 2 h before, during, and 2 h after an HD session by use of a primed constant infusion of l-[1-<jats:sup>13<\/jats:sup>C]leucine and l-[ ring-<jats:sup>2<\/jats:sup>H<jats:sub>5<\/jats:sub>] phenylalanine. Exercise combined with IDPN promoted additive twofold increases in forearm muscle essential amino acid uptake (455 \u00b1 105 vs. 229 \u00b1 38 nmol\u00b7100 ml<jats:sup>-1<\/jats:sup>\u00b7min<jats:sup>-1<\/jats:sup>, P &lt; 0.05) and net muscle protein accretion (125 \u00b1 37 vs. 56 \u00b1 30 \u03bcg\u00b7100 ml<jats:sup>-1<\/jats:sup>\u00b7min<jats:sup>-1<\/jats:sup>, P &lt; 0.05) during HD compared with IDPN alone. Measurements of whole body protein homeostasis and energy expenditure were not altered by exercise treatment. In conclusion, exercise in the presence of adequate nutritional supplementation has potential as a therapeutic intervention to blunt the loss of muscle mass in CHD patients.<\/jats:p>","DOI":"10.1152\/ajpendo.00384.2003","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T20:33:20Z","timestamp":1078864400000},"page":"E589-E597","source":"Crossref","is-referenced-by-count":72,"title":["Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients"],"prefix":"10.1152","volume":"286","author":[{"given":"Lara B.","family":"Pupim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Flakoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna K.","family":"Levenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Alp","family":"Ikizler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.1.137"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.1.E75"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0575f.x"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.4.726"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-11-200112040-00008"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81060-2"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.807"},{"key":"REF8","unstructured":"Garlick PJ, McNurlan MA, McHardy KC, Calder AG, Milne E, Fearns LM, and Broom J.Rates of nutrient utilization in man measured by combined respiratory gas analysis and stable isotopic labeling: effect of food intake.Hum Nutr Clin Nutr41: 177-191, 1987."},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113033"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90139-9"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70276-7"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81083-3"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90307-5"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.339"},{"key":"REF15","doi-asserted-by":"crossref","unstructured":"Ikizler TA, Greene J, Wingard RL, Parker RA, and Hakim RM.Spontaneous dietary protein intake during progression of chronic renal failure.J Am Soc Nephrol6: 1386-1391, 1995.","DOI":"10.1681\/ASN.V651386"},{"key":"REF16","unstructured":"Ikizler TA, Greene JH, Yenicesu M, Schulman G, Wingard RL, and Hakim RM.Nitrogen balance in hospitalized chronic hemodialysis patients.Kidney Int Suppl57: S53-S56, 1996."},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2002.282.1.E107"},{"key":"REF18","doi-asserted-by":"crossref","unstructured":"Ikizler TA, Wingard RL, Sun M, Harvell J, Parker RA, and Hakim RM.Increased energy expenditure in hemodialysis patients.J Am Soc Nephrol7: 2646-2653, 1996.","DOI":"10.1681\/ASN.V7122646"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.07.070187.001155"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00116.x"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00094.2002"},{"key":"REF22","unstructured":"Kopple JD.Causes of catabolism and wasting in acute or chronic renal failure. In:Nephrology, edited by Robinson RR. New York: Springer Verlag, 1984, p. 1498-1515."},{"key":"REF23","doi-asserted-by":"crossref","unstructured":"Kopple JD.National Kidney Foundation K\/DOQI clinical practice guidelines for nutrition in chronic renal failure.Am J Kidney Dis37,Suppl2: S66-S70, 2001.","DOI":"10.1053\/ajkd.2001.20748"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-2276(96)90108-9"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200205000-00016"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.6.E982"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00135.x"},{"key":"REF28","unstructured":"Lowrie EG, Huang WH, Lew NL, and Liu Y.The relative contribution of measured variables to death risk among hemodialysis patients. In:Death on Hemodialysis, edited by Friedman EA. Amsterdam: Kluwer Academic Publishers, 1994, p. 121-141."},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000053910.63105.45"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19940024"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.2337\/diab.12.2.115"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)86021-1"},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50055"},{"key":"REF34","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.78"},{"key":"REF35","doi-asserted-by":"publisher","DOI":"10.1139\/y02-134"},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.1.E99"},{"key":"REF37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215449"},{"key":"REF38","doi-asserted-by":"publisher","DOI":"10.1042\/cs0610627"},{"key":"REF39","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90431-7"},{"key":"REF40","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200150703"},{"key":"REF41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00234.2002"},{"key":"REF42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.00306.x"},{"key":"REF43","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.11.1.109"},{"key":"REF44","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70101-0"},{"key":"REF45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.260.1.E37"},{"key":"REF46","unstructured":"Wasserman K.Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications.Philadelphia, PA: Lippincott Williams & Wilkins, 1999."},{"key":"REF47","unstructured":"Wolfe RR.Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis, edited by Wolfe RR. New York: Wiley-Liss, 1992."},{"key":"REF48","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.2.551S"},{"key":"REF49","doi-asserted-by":"crossref","unstructured":"Wolfe RR.Effects of amino acid intake on anabolic processes.Can J Appl Physiol26,Suppl: S220-S227, 2001.","DOI":"10.1139\/h2001-056"},{"key":"REF50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.1992.tb00231.x"},{"key":"REF51","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.52"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00384.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T02:19:07Z","timestamp":1623723547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00384.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1152\/ajpendo.00384.2003"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00384.2003","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}