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We studied the effect of early light-phase injection of PYY<jats:sub>3-36<\/jats:sub> on food intake in mice fasted for 0, 6, 12, 18, 24, and 30 h and show that PYY<jats:sub>3-36<\/jats:sub> produces an acute anorexigenic effect regardless of the duration of fasting. We also show evidence of a delayed orexigenic effect in ad libitum-fed mice injected with PYY<jats:sub>3-36<\/jats:sub> in the early light phase. This delayed orexigenic effect also occurs in mice administered a potent analog of PYY<jats:sub>3-36<\/jats:sub>, d-Allo Ile<jats:sup>3<\/jats:sup> PYY<jats:sub>3-36<\/jats:sub>, but not following injection of other anorectic agents (glucagon-like-peptide 1, oxyntomodulin, and lithium chloride). Early light-phase injection of PYY<jats:sub>3-36<\/jats:sub> to ad libitum-fed mice resulted in a trend toward increased levels of hypothalamic NPY and agouti-related peptide mRNA and a decrease in proopiomelanocortin mRNA at the beginning of the dark phase. Furthermore, plasma levels of ghrelin were increased significantly, and there was a trend toward decreased plasma PYY<jats:sub>3-36<\/jats:sub> levels at the beginning of the dark phase. These data indicate that PYY<jats:sub>3-36<\/jats:sub> injection results in an acute anorexigenic effect followed by a delayed orexigenic effect. <\/jats:p>","DOI":"10.1152\/ajpendo.00405.2007","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T23:34:08Z","timestamp":1203464048000},"page":"E698-E708","source":"Crossref","is-referenced-by-count":28,"title":["PYY<sub>3-36<\/sub> injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones"],"prefix":"10.1152","volume":"294","author":[{"given":"James R. 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