{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:26:57Z","timestamp":1666600017287},"reference-count":27,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p> Adrenal androgen production is reduced in association with disease severity in HIV-infected women. This response may be maladaptive in terms of maintenance of lean body mass, functional status, and immune function. The aim of this study was to assess whether the use of an adrenal enzyme inhibitor of 11\u03b2-hydroxylase might increase androgen production in this population. We conducted a randomized, double-blind, placebo-controlled study of metyrapone (500 mg po qid) or placebo for 2 wk in 10 HIV-infected women with AIDS wasting [weight &lt;90% ideal body weight (IBW) or weight loss &gt;10%] and reduced androgen levels. Basal and ACTH-stimulated androgen, mineralocorticoid, and glucocorticoid levels were measured at baseline and after 14 days of treatment. Subjects were similar in age (40.9 \u00b1 0.9 yr), weight (91.7 \u00b1 3.5% IBW) and hormone concentrations at study entry. Total testosterone (84 \u00b1 54 vs. \u22120.4 \u00b1 2 ng\/dl, P = 0.024), free testosterone (6.5 \u00b1 2.8 vs. 0.1 \u00b1 0.1 pg\/ml, P = 0.024), DHEA (5.0 \u00b1 3.2 vs. \u22120.6 \u00b1 0.5 \u03bcg\/l, P = 0.024), and 11-deoxycortisol (2,145 \u00b1 820 vs. \u221214 \u00b1 22 ng\/dl, P = 0.024) levels increased in response to metyrapone compared with placebo treatment. In response to ACTH, significant increases in the DHEA\/cortisol ratio (174 \u00b1 48 vs. 3 \u00b1 3, P = 0.008) were seen in the metyrapone group compared with placebo. Blood pressure and electrolytes did not change, and signs of adrenal insufficiency were not apparent. These data demonstrate that inhibition of 11\u03b2-hydroxylase with metyrapone increases adrenal androgen secretion in HIV-infected women. Further studies are needed to assess the physiological effects of this strategy to increase anabolic hormone levels in severe stress, including detailed testing to rule out the potential risk of concomitant adrenal insufficiency. <\/jats:p>","DOI":"10.1152\/ajpendo.00418.2005","type":"journal-article","created":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T01:33:43Z","timestamp":1132709623000},"page":"E808-E813","source":"Crossref","is-referenced-by-count":2,"title":["Increased adrenal androgen secretion with inhibition of 11\u03b2-hydroxylase in HIV-infected women"],"prefix":"10.1152","volume":"290","author":[{"given":"Polyxeni","family":"Koutkia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Breu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Grinspoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861553"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00015-2"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Christeff N, Lortholary O, Casassus P, Thobie N, Veyssier P, Torri O, Guillevin L, and Nunez EA. 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