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Pregnant Gcgr<jats:sup>\u2212\/\u2212<\/jats:sup>female mice displayed persistent hypoglycemia and hyperglucagonemia. Gcgr<jats:sup>\u2212\/\u2212<\/jats:sup>pregnancies were associated with decreased fetal weight, increased late-gestation fetal demise, and significant abnormalities of placentation. Gcgr<jats:sup>\u2212\/\u2212<\/jats:sup>placentas contained areas of extensive mineralization, fibrinoid necrosis, narrowing of the vascular channels, and a thickened interstitium associated with trophoblast hyperplasia. Absent glucagon signaling did not alter glycogen content in Gcgr<jats:sup>\u2212\/\u2212<\/jats:sup>placentas but significantly downregulated genes that control growth, adrenergic signaling, vascularization, oxidative stress, and G protein-coupled receptors. 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