{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:23:48Z","timestamp":1776277428109,"version":"3.50.1"},"reference-count":39,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p> Narcolepsy is a sleep disorder caused by impaired hypocretin (orexin) neurotransmission. Growth hormone (GH) secretion may be altered in narcolepsy for various reasons. Slow-wave sleep episodes, which are closely associated with GH-secretory events, are more randomly dispersed over 24 h in narcoleptics. Furthermore, hypocretins may inhibit pituitary GH release. We assessed the function of the somatotropic axis in narcolepsy by deconvolving 24-h (10-min sampling interval) plasma GH concentration profiles in seven hypocretin-deficient narcoleptic patients and in seven healthy controls matched for age, sex, and body weight. Both basal and pulsatile GH secretion rate and secretagogue-induced GH release were similar in patients and controls. However, narcoleptics secreted \u223c50% of their total production during the daytime, whereas controls secreted only 25% during the day. Also, the GH output pattern of narcoleptics was significantly less regular. We propose that hypocretin deficiency disrupts the circadian distribution of hypothalamic GH-releasing hormone release in narcoleptic patients to simultaneously cause daytime GH release and promote their propensity to fall asleep during the day. <\/jats:p>","DOI":"10.1152\/ajpendo.00421.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T14:51:48Z","timestamp":1425394308000},"page":"E641-E647","source":"Crossref","is-referenced-by-count":41,"title":["Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events"],"prefix":"10.1152","volume":"284","author":[{"given":"Sebastiaan","family":"Overeem","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon W.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, 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