{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:20:31Z","timestamp":1771629631000,"version":"3.50.1"},"reference-count":59,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:p>Exaggerated secretion of glucagon-like peptide 1 (GLP-1) is important for postprandial glucose tolerance after Roux-en-Y gastric bypass (RYGB), whereas the role of glucose-dependent insulinotropic polypeptide (GIP) remains to be resolved. We aimed to explore the relative importance of endogenously secreted GLP-1 and GIP on glucose tolerance and \u03b2-cell function after RYGB. We used DPP-4 inhibition to enhance concentrations of intact GIP and GLP-1 and the GLP-1 receptor antagonist exendin-(9\u201339) (Ex-9) for specific blockage of GLP-1 actions. Twelve glucose-tolerant patients were studied after RYGB in a randomized, placebo-controlled, 4-day crossover study with standard mixed-meal tests and concurrent administration of placebo, oral sitagliptin, Ex-9 infusion, or combined Ex-9-sitagliptin. GLP-1 receptor antagonism increased glucose excursions, clearly attenuated \u03b2-cell function, and aggravated postprandial hyperglucagonemia compared with placebo, whereas sitagliptin had no effect despite two- to threefold increased concentrations of intact GLP-1 and GIP. Similarly, sitagliptin did not affect glucose tolerance or \u03b2-cell function during GLP-1R blockage. This study confirms the importance of GLP-1 for glucose tolerance after RYGB via increased insulin and attenuated glucagon secretion in the postprandial state, whereas amplification of the GIP signal (or other DPP-4-sensitive glucose-lowering mechanisms) did not appear to contribute to the improved glucose tolerance seen after RYGB.<\/jats:p>","DOI":"10.1152\/ajpendo.00471.2015","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T04:54:24Z","timestamp":1453265664000},"page":"E505-E514","source":"Crossref","is-referenced-by-count":63,"title":["Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery"],"prefix":"10.1152","volume":"310","author":[{"given":"Maria S.","family":"Svane","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark;"},{"name":"NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of 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