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Since traditional wisdom holds that the hypothalamus primarily controls glucose homeostasis, the brainstem, although less studied, has been emerging as a key player in blood glucose metabolism. Although the brainstem is reciprocally wired with the hypothalamus, their interactions are crucial for glucose control. Here, we focus on classic discoveries and recent advancements of hypothalamic and brainstem nodes that regulate glucose homeostasis. Based on the current progress and development for central regulation of blood sugar, we propose that the circuitry and cellular mechanisms for how hypothalamus and brainstem coordinate in blood sugar regulation are crucial; hence, a deeper understanding of both nuclei could shed light on a future cure for diabetes.<\/jats:p>","DOI":"10.1152\/ajpendo.00474.2024","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:50:30Z","timestamp":1741243830000},"page":"E588-E598","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypothalamus and brainstem circuits in the regulation of glucose homeostasis"],"prefix":"10.1152","volume":"328","author":[{"given":"Zitian","family":"Lin","sequence":"first","affiliation":[{"name":"Zhejiang University","place":["People\u2019s Republic of 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