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Oral glucose tolerance tests were performed before beginning HFD (OGTT1), 4 wk after HFD began (Bromo only), and after 7.5 wk on HFD (OGTT3). After 8 wk on HFD, clamp studies were performed, with infusion of somatostatin and intraportal replacement of insulin (4\u00d7 basal) and glucagon (basal). From 0 to 90 min (P1), glucose was infused via peripheral vein to double the hepatic glucose load; and from 90 to 180 min (P2), glucose was infused via the hepatic portal vein at 4 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>, with the HGL maintained at 2\u00d7 basal. Bromo decreased the OGTT glucose \u0394AUC<jats:sub>0\u201330<\/jats:sub>and \u0394AUC<jats:sub>0\u2013120<\/jats:sub>by 62 and 27%, respectively, P &lt; 0.05 for both) without significantly altering the insulin response. Bromo dogs exhibited enhanced net hepatic glucose uptake (NHGU) compared with CTR (~33 and 21% greater, P1 and P2, respectively, P &lt; 0.05). Nonhepatic glucose uptake (non-HGU) was increased ~38% in Bromo in P2 ( P &lt; 0.05). Bromo vs. CTR had higher ( P &lt; 0.05) rates of glucose infusion (36 and 30%) and non-HGU (~40 and 27%) than CTR during P1 and P2, respectively. In Bromo vs. CTR, hepatic 18:0\/16:0 and 16:1\/16:0 ratios tended to be elevated in triglycerides and were higher ( P &lt; 0.05) in phospholipids, consistent with a beneficial effect of bromocriptine on liver fat accumulation. Thus, bromocriptine treatment improved glucose disposal in a glucose-intolerant model, enhancing both NHGU and non-HGU.<\/jats:p>","DOI":"10.1152\/ajpendo.00479.2019","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T19:16:13Z","timestamp":1590606973000},"page":"E133-E145","source":"Crossref","is-referenced-by-count":3,"title":["Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model"],"prefix":"10.1152","volume":"319","author":[{"given":"Mary Courtney","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Metabolic Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Metabolic Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, 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