{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:50:39Z","timestamp":1769205039313,"version":"3.49.0"},"reference-count":54,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["08\/088A"],"award-info":[{"award-number":["08\/088A"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["09\/095"],"award-info":[{"award-number":["09\/095"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p> Fetal growth restriction (FGR) is associated with compromised growth and metabolic function throughout life. Intrauterine therapy of FGR with intra-amniotic insulin-like growth factor-1 (IGF1) enhances fetal growth and alters perinatal metabolism and growth in a sex-specific manner, but the adult effects are unknown. We investigated the effects of intra-amniotic IGF1 treatment of FGR on adult growth and body composition, adrenergic sensitivity, and glucose-insulin axis regulation. Placental embolization-induced FGR was treated with four weekly doses of 360 \u00b5g intra-amniotic IGF1 (FGRI) or saline (FGRS). Offspring were raised to adulthood (18 mo: FGRI, n = 12 females, 12 males; FGRS, n = 13 females, 10 males) alongside offspring from unembolized and untreated sheep (CON; n = 12 females, 21 males). FGRI females had increased relative lean mass compared with CON but not FGRS ( P &lt; 0.05; 70.6\u2009\u00b1\u20098.2% vs. 61.4\u2009\u00b1\u20098.2% vs. 67.6\u2009\u00b1\u20098.2%), decreased abdominal adipose compared with CON and FGRS ( P &lt; 0.05; 43.7\u2009\u00b1\u20091.2% vs. 49.3\u2009\u00b1\u20090.9% vs. 48.5\u2009\u00b1\u20091.0%), increased glucose utilization compared with FGRS but not CON ( P &lt; 0.05; 9.6\u2009\u00b1\u20091.0 vs. 6.0\u2009\u00b1\u20090.9 vs. 7.6\u2009\u00b1\u20090.9 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), and increased \u03b2-hydroxybutyric acid:nonesterified fatty acid ratio in response to adrenaline compared with CON and FGRS ( P &lt; 0.05; 3.9\u2009\u00b1\u20091.4 vs. 1.1\u2009\u00b1\u20091.4 vs. 1.8\u2009\u00b1\u20091.4). FGRS males were smaller and lighter compared with CON but not FGRI ( P &lt; 0.05; 86.8\u2009\u00b1\u20096.3 vs. 93.5\u2009\u00b1\u20096.1 vs. 90.7\u2009\u00b1\u20096.3 kg), with increased peak glucose concentration (10%) in response to a glucose load but few other differences. These effects of intra-amniotic IGF1 therapy on adult body composition, glucose-insulin axis function, and adrenergic sensitivity could indicate improved metabolic regulation during young adulthood in female FGR sheep. <\/jats:p>","DOI":"10.1152\/ajpendo.00481.2019","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T16:18:56Z","timestamp":1582733936000},"page":"E568-E578","source":"Crossref","is-referenced-by-count":9,"title":["Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex specific"],"prefix":"10.1152","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-8048","authenticated-orcid":false,"given":"Ana-Mishel","family":"Spiroski","sequence":"first","affiliation":[{"name":"The Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Hope","family":"Oliver","sequence":"additional","affiliation":[{"name":"The Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Louise","family":"Jaquiery","sequence":"additional","affiliation":[{"name":"The Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis Dane","family":"Gunn","sequence":"additional","affiliation":[{"name":"The Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane Elizabeth","family":"Harding","sequence":"additional","affiliation":[{"name":"The Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-6577","authenticated-orcid":false,"given":"Frank 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