{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:29:21Z","timestamp":1773286161638,"version":"3.50.1"},"reference-count":19,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:p>Recently, we proposed a model describing the suppression of endogenous glucose production (EGP) during a meal. It assumes that EGP suppression depends on glucose concentration and its rate of change and on delayed insulin action. Hepatic insulin sensitivity (S<jats:sub>I<\/jats:sub><jats:sup>Lmeal<\/jats:sup>) can be derived from EGP model parameters. This model was shown to adequately describe EGP profiles measured with multiple tracer techniques; however, S<jats:sub>I<\/jats:sub><jats:sup>Lmeal<\/jats:sup>has never been compared directly with its euglycemic hyperinsulinemic clamp counterpart (S<jats:sub>I<\/jats:sub><jats:sup>Lclamp<\/jats:sup>). To do so, 62 subjects with different degrees of glucose tolerance underwent a triple-tracer mixed meal. Fifty-seven subjects also underwent a labeled ([3-<jats:sup>3<\/jats:sup>H]glucose) euglycemic hyperinsulinemic clamp. From the triple-tracer meal data, virtually model-independent estimates of EGP were obtained using the tracer-to-tracee clamp technique, and the EGP model was identified in each subject. Model fit was satisfactory, and S<jats:sub>I<\/jats:sub><jats:sup>Lmeal<\/jats:sup>was estimated with good precision. Correlation between S<jats:sub>I<\/jats:sub><jats:sup>Lclamp<\/jats:sup>and S<jats:sub>I<\/jats:sub><jats:sup>Lmeal<\/jats:sup>was good ( r = 0.72, P &lt; 0.001); however, S<jats:sub>I<\/jats:sub><jats:sup>Lmeal<\/jats:sup>was lower than S<jats:sub>I<\/jats:sub><jats:sup>Lclamp<\/jats:sup>(4.60 \u00b1 0.64 vs. 8.73 \u00b1 1.07 10<jats:sup>\u22124<\/jats:sup>dl\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>per \u03bcU\/ml, P &lt; 0.01). This difference may be due to different ranges of insulin explored during the two tests (\u0394I<jats:sup>clamp<\/jats:sup>= 15.60 \u00b1 1.61 vs. \u0394I<jats:sup>meal<\/jats:sup>= 83.37 \u00b1 10.71 \u03bcU\/ml) as well as steady- vs. non-steady-state glucose and insulin profiles. In conclusion, the new EGP model provides an estimate of hepatic insulin sensitivity during a meal that is in good agreement with that derived in the same individuals with a hyperinsulinemic clamp. When used in conjunction with the minimal model, the approach potentially enables estimation of hepatic insulin sensitivity from a single-tracer labeled meal or oral glucose tolerance test.<\/jats:p>","DOI":"10.1152\/ajpendo.00482.2012","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T08:29:22Z","timestamp":1361953762000},"page":"E819-E825","source":"Crossref","is-referenced-by-count":22,"title":["Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp"],"prefix":"10.1152","volume":"304","author":[{"given":"Chiara","family":"Dalla Man","sequence":"first","affiliation":[{"name":"Department of Information Engineering, University of Padua, Padua, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Piccinini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padua, Padua, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Basu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Basu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Rizza","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Cobelli","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padua, Padua, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1519"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1464-5491.2008.02597.x","volume":"25","author":"Abdul-Ghani MA","year":"2008","journal-title":"Diabet Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00190.2001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1692"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-6-1-45"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0319"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1272"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1776"},{"key":"B9","volume-title":"Introduction to Modeling in Physiology and Medicine","author":"Cobelli C","year":"2008"},{"key":"B10","volume-title":"Tracer Kinetics in Biomedical Research: From Data to Model","author":"Cobelli C","year":"2000"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.3.E481"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00319.2003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00299.2004"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00486.2007"},{"key":"B15","first-page":"E214","volume":"237","author":"DeFronzo RA","year":"1979","journal-title":"Am J Physiol Endocrinol Metab Gastrointest Physiol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112467"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"B18","first-page":"E84","volume":"234","author":"Radziuk J","year":"1978","journal-title":"Am J Physiol Endocrinol Metab Gastrointest Physiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.11.2197"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00482.2012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T14:39:12Z","timestamp":1715006352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00482.2012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,4,15]]}},"alternative-id":["10.1152\/ajpendo.00482.2012"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00482.2012","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}