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In this study, we examined the effect of mifepristone, a glucocorticoid (GC) receptor antagonist, on limiting adipose tissue mass gain and preserving whole body insulin sensitivity following the cessation of daily running and CR. We calorically restricted male Sprague-Dawley rats and provided access to voluntary running wheels for 3 wk followed by locking of the wheels and reintroduction to ad libitum feeding with or without mifepristone (80 mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for 1 wk. Cessation of daily running and CR increased HOMA-IR and visceral adipose mass as well as glucose and insulin area under the curve during an oral glucose tolerance test vs. pre-wheel lock exercised rats and sedentary rats (all P &lt; 0.05). Insulin sensitivity and glucose tolerance were preserved and adipose tissue mass gain was attenuated by daily mifepristone treatment during the post-wheel lock period. These findings suggest that following regular exercise and CR there are GC-induced mechanisms that promote adipose tissue mass gain and impaired metabolic control in healthy organisms and that this phenomenon can be inhibited by the GC receptor antagonist mifepristone.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00490.2015","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T23:28:05Z","timestamp":1462318085000},"page":"E56-E68","source":"Crossref","is-referenced-by-count":9,"title":["Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction"],"prefix":"10.1152","volume":"311","author":[{"given":"Trevor","family":"Teich","sequence":"first","affiliation":[{"name":"Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, 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