{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:40:06Z","timestamp":1793378406574,"version":"4.5.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism, oligo\/amenorrhea, and polycystic ovaries. We aimed to determine whether low-frequency electro-acupuncture (EA) would decrease hyperandrogenism and improve oligo\/amenorrhea more effectively than physical exercise or no intervention. We randomized 84 women with PCOS, aged 18\u201337 yr, to 16 wk of low-frequency EA, physical exercise, or no intervention. The primary outcome measure changes in the concentration of total testosterone (T) at week 16 determined by gas and liquid chromatography-mass spectrometry was analyzed by intention to treat. Secondary outcome measures were changes in menstrual frequency; concentrations of androgens, estrogens, androgen precursors, and glucuronidated androgen metabolites; and acne and hirsutism. Outcomes were assessed at baseline, after 16 wk of intervention, and after a 16-wk follow-up. After 16 wk of intervention, circulating T decreased by \u221225%, androsterone glucuronide by \u221230%, and androstane-3\u03b1,17\u03b2-diol-3-glucuronide by \u221228% in the EA group ( P = 0.038, 0.030, and 0.047, respectively vs. exercise); menstrual frequency increased to 0.69\/month from 0.28 at baseline in the EA group ( P = 0.018 vs. exercise). After the 16-wk follow-up, the acne score decreased by \u221232% in the EA group ( P = 0.006 vs. exercise). Both EA and exercise improved menstrual frequency and decreased the levels of several sex steroids at week 16 and at the 16-wk follow-up compared with no intervention. Low-frequency EA and physical exercise improved hyperandrogenism and menstrual frequency more effectively than no intervention in women with PCOS. Low-frequency EA was superior to physical exercise and may be useful for treating hyperandrogenism and oligo\/amenorrhea.<\/jats:p>","DOI":"10.1152\/ajpendo.00495.2010","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T03:01:40Z","timestamp":1287025300000},"page":"E37-E45","source":"Crossref","is-referenced-by-count":171,"title":["Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo\/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial"],"prefix":"10.1152","volume":"300","author":[{"given":"Elizabeth","family":"Jedel","sequence":"first","affiliation":[{"name":"Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernand","family":"Labrie","sequence":"additional","affiliation":[{"name":"Laval University Research Center in Molecular Endocrinology, Oncology and Human Genomics, CHUL Research Center, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Od\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Holm","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Department of Metabolism and Cardiovascular Disease,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science, Department of Obstetrics and Gynecology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Olof","family":"Janson","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science, Department of Obstetrics and Gynecology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Lind","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science, Department of Obstetrics and Gynecology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Center for Bone and Arthritis Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Stener-Victorin","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of G\u00f6teborg, Gothenburg, Sweden; 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