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After feeding a high-fat diet (HFD) for 24 wk, IRF7 knockout (KO) mice showed less weight gain and adiposity than wild-type controls. KO of IRF7 improved glucose and lipid homeostasis and insulin sensitivity. Additionally, KO of IRF7 ameliorated diet-induced hepatic steatosis. Next, we assessed the inflammatory state of the IRF7 KO mice on the HFD. These mice showed less macrophage infiltration into multiple organs and were protected from local and systemic inflammation. This study demonstrates a role for IRF7 in diet-induced alterations in energy metabolism and insulin sensitivity. Our results also suggest that IRF7 is involved in the etiology of metabolic abnormalities, which suggests a new strategy for treating obesity and type 2 diabetes.<\/jats:p>","DOI":"10.1152\/ajpendo.00505.2012","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T01:04:44Z","timestamp":1369184684000},"page":"E485-E495","source":"Crossref","is-referenced-by-count":105,"title":["Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance"],"prefix":"10.1152","volume":"305","author":[{"given":"Xin-An","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China;"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Laboratory of Medical Molecular Biology, Institute of Basic Medical 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