{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:15:58Z","timestamp":1777630558151,"version":"3.51.4"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>Thyrotoxicosis is frequently associated with increased bone turnover and decreased bone mass. To investigate the role of thyroid hormone receptor-\u03b2 (TR\u03b2) in mediating the osteopenic effects of triiodothyronine (T<jats:sub>3<\/jats:sub>), female adult rats were treated daily (64 days) with GC-1 (1.5 \u03bcg\/100 g body wt), a TR\u03b2-selective thyromimetic compound. Bone mass was studied by dual-energy X-ray absorptiometry of several skeletal sites and histomorphometry of distal femur, and the results were compared with T<jats:sub>3<\/jats:sub>-treated (3 \u03bcg\/100 g body wt) or control animals. As expected, treatment with T<jats:sub>3<\/jats:sub>significantly reduced bone mineral density (BMD) in the lumbar vertebrae (L<jats:sub>2<\/jats:sub>-L<jats:sub>5<\/jats:sub>), femur, and tibia by 10\u201315%. In contrast, GC-1 treatment did not affect the BMD in any of the skeletal sites studied. The efficacy of GC-1 treatment was verified by a reduction in serum TSH (\u201352% vs. control, P &lt; 0.05) and cholesterol (\u201321% vs. control, P &lt; 0.05). The histomorphometric analysis of the distal femur indicated that T<jats:sub>3<\/jats:sub>but not GC-1 treatment reduced the trabecular volume, thickness, and number. We conclude that chronic, selective activation of the TR\u03b2 isoform does not result in bone loss typical of T<jats:sub>3<\/jats:sub>-induced thyrotoxicosis, suggesting that the TR\u03b2 isoform is not critical in this process. In addition, our findings suggest that the development of TR-selective T<jats:sub>3<\/jats:sub>analogs that spare bone mass represents a significant improvement toward long-term TSH-suppressive therapy.<\/jats:p>","DOI":"10.1152\/ajpendo.00506.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:53:39Z","timestamp":1425412419000},"page":"E1135-E1141","source":"Crossref","is-referenced-by-count":53,"title":["Spared bone mass in rats treated with thyroid hormone receptor TR\u03b2-selective compound GC-1"],"prefix":"10.1152","volume":"285","author":[{"given":"Fatima R. 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