{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:10:12Z","timestamp":1782123012401,"version":"3.54.5"},"reference-count":48,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["14-15-00392"],"award-info":[{"award-number":["14-15-00392"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Alcoholic myopathy is characterized by the reduction in cross-sectional area (CSA) of muscle fibers and impaired anabolic signaling. The goal of the current study was to investigate the causes and compare the changes in CSA and fiber type composition with the modifications of anabolic and catabolic signaling pathways at the early stages of chronic alcohol consumption in women. Skeletal muscle samples from 5 female patients with alcohol abuse (AL; 43\u2009\u00b1\u20095 yr old; alcohol abuse duration 5,6\u2009\u00b1\u20090,6 yr) were compared with the muscle from the control group of 8 healthy women (C; 35\u2009\u00b1\u20094 yr old). The average daily dose of alcohol consumption was 110\u2009\u00b1\u200910 ml of pure ethanol. In women patients, a significant decrease in CSA of type I and II muscle fibers, titin and nebulin content, plasma IGF-1 level and total IRS-1, p-Akt and p-4E-BP1 in vastus lateralis was found in comparison with the control group. The p-AMPK level was found to be increased versus the control group. In women patients with chronic alcoholic myopathy 1) both fast and slow muscle fibers are subjected to atrophy; 2) impairments in IGF-I-dependent signaling and pathways controlling translation initiation (AMPK\/mTOR\/4E-BP1), but not translation elongation, are observed; 3) the level of calpain-1 and ubiquitinated proteins increases, unlike E3 ligases content.<\/jats:p>","DOI":"10.1152\/ajpendo.00513.2018","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T18:57:49Z","timestamp":1553626669000},"page":"E967-E976","source":"Crossref","is-referenced-by-count":22,"title":["Cellular and molecular signatures of alcohol-induced myopathy in women"],"prefix":"10.1152","volume":"316","author":[{"given":"Boris S.","family":"Shenkman","sequence":"first","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga E.","family":"Zinovyeva","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana P.","family":"Belova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1986-6221","authenticated-orcid":false,"given":"Timur M.","family":"Mirzoev","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Vilchinskaya","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-6789","authenticated-orcid":false,"given":"Ivan M.","family":"Vikhlyantsev","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Pushchino, Russia"},{"name":"Pushchino State Institute of Natural Science, Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna D.","family":"Ulanova","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Pushchino, Russia"},{"name":"Pushchino State Institute of Natural Science, Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Turtikova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nudlya D.","family":"Samkhaeva","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Parfenov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey N.","family":"Barinov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Russian Ministry of Health, Moscow, Russia"},{"name":"Interventional Medicine A\u0441ademy, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana L.","family":"Nemirovskaya","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(03)00114-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200171200"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.01.001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.050245"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.59"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-4-S1-S8"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/378785a0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.11.6242"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.01.012"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4683"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0445-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02493.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/09595239600186021"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.161"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0203-87"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1139\/H09-137"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13476"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.9.991"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12174"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/323160a0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.4.1154"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00141-1"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.81"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00076"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.02.011"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00603.2006"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4279"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-204412"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20743"},{"key":"B31","first-page":"55","volume":"23","author":"Mumenthaler MS","year":"1999","journal-title":"Alcohol Res Health"},{"key":"B32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7868\/S0131164615060041","volume":"41","author":"Nemirovskaya TL","year":"2015","journal-title":"Fiziol Cheloveka"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00037"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096378"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.203232"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.050526"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00469.2004"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328352b4c2"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00582.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/biom5043193"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.08.026"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13531"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00006.2015"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1995.1004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297912130093"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0266-6"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.148338"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416618-9.00013-3"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00513.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T05:11:04Z","timestamp":1721106664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00513.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,1]]}},"alternative-id":["10.1152\/ajpendo.00513.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00513.2018","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}