{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:00:09Z","timestamp":1781204409705,"version":"3.54.1"},"reference-count":58,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Cellular Longevity Inc."}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>This study validates the efficacy of the thiazolidinediones (TZD) drug pioglitazone in a fat-fed canine model. Using a novel principal component analysis integrating multimodal data (fasting metabolites, OGTT, and clamp results), we demonstrate that pioglitazone effectively reverses diet-induced glucose intolerance and significantly improves insulin sensitivity. Mechanistically, this improvement is driven by adiponectin action. These findings provide strong evidence supporting TZD use as a prophylactic tool for mitigating metabolic syndrome.<\/jats:p>","DOI":"10.1152\/ajpendo.00515.2025","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:21:26Z","timestamp":1779405686000},"page":"E35-E48","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pioglitazone increases adiponectin and attenuates the appearance of diet-induced insulin resistance in high-fat-fed beagles"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-4725","authenticated-orcid":false,"given":"Guillaume","family":"Kraft","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Tovar","sequence":"additional","affiliation":[{"name":"Cellular Longevity Inc.","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalisha","family":"Yankey","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Scott","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Graves","sequence":"additional","affiliation":[{"name":"Cellular Longevity Inc.","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Farmer","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Peloquin","sequence":"additional","affiliation":[{"name":"Cellular Longevity Inc.","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-2560","authenticated-orcid":false,"given":"Alan D.","family":"Cherrington","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.169078"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101502"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.363960"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1163"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1745"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060326"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922169117"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nm788"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051425"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158298"},{"key":"B11","first-page":"29","volume":"47","author":"Maeshiba Y","year":"1997","journal-title":"Arzneimittelforschung"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.2.224"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158703"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1209"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00479.2019"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00372.2010"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.1.E147"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.23.11.0253"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.801863"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296400"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63373-5"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0642-z"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00015.2015"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02986.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.5.529"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24156"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00380.2007"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.1.E126"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118410"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)43098-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1980.sp002492"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.2.E400"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90051-9"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1037\/h0071325"},{"key":"B35","unstructured":"Husson F, Josse J, Le S, Mazet J, Husson M. Package \u2018FactoMineR\u2019. Multivariate Exploratory Data Analysis and Data Mining. Vienna, Austria: CRAN, 2020. cran.r-project.org\/web\/packages\/FactoMineR\/index.html."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v025.i01"},{"key":"B37","doi-asserted-by":"publisher","unstructured":"Kassambara A. Factoextra: Extract and Visualize the Results of Multivariate Data Analyses. R Package Version 1. Vienna, Austria: CRAN, 2016. doi:10.32614\/cran.package.factoextra.","DOI":"10.32614\/cran.package.factoextra"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2147\/VMRR.S40868"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.249"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-017-0290-5"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/97125"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.134"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2445"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90892.2008"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.042"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.04.008"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00083.2014"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.145359"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1863"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.2.E275"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.4.E709"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1872"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042220-023633"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21752"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nm780"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051021"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.9.1018"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2337\/db24-1563-P"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00515.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:25:43Z","timestamp":1781202343000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00515.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/ajpendo.00515.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00515.2025","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}