{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:34:05Z","timestamp":1787726045390,"version":"build-2784847793"},"reference-count":55,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["214900"],"award-info":[{"award-number":["214900"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["212319 and 226049"],"award-info":[{"award-number":["212319 and 226049"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"EC | HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101095433"],"award-info":[{"award-number":["101095433"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>Acute IL-1 blockade with anakinra markedly reduced CRP and leukocyte counts within 12 h, demonstrating rapid anti-inflammatory efficacy. Anakinra induced a trend toward earlier insulin secretion and significantly increased postprandial IL-6 and GLP-1 levels. The study demonstrates that even short-term IL-1 blockade can modulate both immune and incretin responses in prediabetes. Early IL-1\u03b2 antagonism may represent a preventive, anti-inflammatory approach to preserve GLP-1 secretion and \u03b2-cell function in individuals with prediabetes.<\/jats:p>","DOI":"10.1152\/ajpendo.00527.2025","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:10:33Z","timestamp":1772622633000},"page":"E500-E509","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute interleukin-1\u03b2 antagonism decreases systemic inflammation, increases GLP-1 release, and modulates insulin secretion in individuals with prediabetes"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0634-7723","authenticated-orcid":false,"given":"Justus S.","family":"Fischer","sequence":"first","affiliation":[{"name":"University of Basel","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-6235","authenticated-orcid":false,"given":"Matthias","family":"Hepprich","sequence":"additional","affiliation":[{"name":"University of Basel","place":["Switzerland"]},{"name":"St. Claraspital Basel","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8431","authenticated-orcid":false,"given":"Marco","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"University of Basel","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Seeger","sequence":"additional","affiliation":[{"name":"University of Basel","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dobler","sequence":"additional","affiliation":[{"name":"Hospital Dornach","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-5045","authenticated-orcid":false,"given":"Marc Y.","family":"Donath","sequence":"additional","affiliation":[{"name":"University of Basel","place":["Switzerland"]},{"name":"University and University Hospital of Montreal","place":["Canada"]},{"name":"Cantonal Hospital Baden","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00033-X"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14388"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05592-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00745-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2019.6.01"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3405"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00932-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065213"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3659"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06306-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.063"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0213-9"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103250"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-3008"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154957"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00385-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1210\/10.1210\/er.2006-0038"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0893"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12357"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2992"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00620.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2005.026252"},{"key":"B25","volume-title":"R Foundation for Statistical Computing","author":"R Core Team","year":"2024"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.198"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.s265"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.033"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0371"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00482-9"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05956-x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab337"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3346"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.034"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2724-5"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612459675"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0264"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103910"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00610-8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01479-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0863"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1650"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.001"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030202"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nature04634"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000847"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00739"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141550"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.043"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.044"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.008"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2513"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.02.013"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05040-3"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00527.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:26:55Z","timestamp":1778009215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00527.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/ajpendo.00527.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00527.2025","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}