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Given the size, capacity, and dynamic range of the NKA pool in skeletal muscle, its tight regulation is essential to maintain whole body homeostasis as well as muscle function. To reconcile functional needs of systemic homeostasis with those of skeletal muscle, NKA is regulated in a coordinated manner by extrinsic stimuli, such as hormones and nerve-derived factors, as well as by local stimuli arising in skeletal muscle fibers, such as contractions and muscle energy status. These stimuli regulate NKA acutely by controlling its enzymatic activity and\/or its distribution between the plasma membrane and the intracellular storage compartment. They also regulate NKA chronically by controlling NKA gene expression, thus determining total NKA content in skeletal muscle and its maximal pumping capacity. This review focuses on molecular mechanisms that underlie regulation of NKA in skeletal muscle by major extrinsic and local stimuli. Special emphasis is given to stimuli and mechanisms linking regulation of NKA and energy metabolism in skeletal muscle, such as insulin and the energy-sensing AMP-activated protein kinase. Finally, the recently uncovered roles for glutathionylation, nitric oxide, and extracellular K\n                    <jats:sup>+<\/jats:sup>\n                    in the regulation of NKA in skeletal muscle are highlighted.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00539.2015","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T01:56:27Z","timestamp":1462931787000},"page":"E1-E31","source":"Crossref","is-referenced-by-count":116,"title":["Na,K-ATPase regulation in skeletal muscle"],"prefix":"10.1152","volume":"311","author":[{"given":"Sergej","family":"Pirkmajer","sequence":"first","affiliation":[{"name":"Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Chibalin","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 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