{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:11:26Z","timestamp":1790338286492,"version":"4.1.0"},"reference-count":51,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1157930"],"award-info":[{"award-number":["APP1157930"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["APP1157930"],"award-info":[{"award-number":["APP1157930"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:p> Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g\/kg glucose) mixed-nutrient meal (10 kcal\/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (\u221225%, \u221227%, and \u221246%, respectively; all P &lt; 0.05) and to a greater extent at 120 min postprandial (\u221237%, \u221246%, and \u221264%; all P &lt; 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P &lt; 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction ( R<jats:sup>2<\/jats:sup>\u2009=\u20090.742; P &lt; 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial. <\/jats:p>","DOI":"10.1152\/ajpendo.00540.2019","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T18:39:19Z","timestamp":1586889559000},"page":"E1014-E1021","source":"Crossref","is-referenced-by-count":19,"title":["High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men"],"prefix":"10.1152","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-1851","authenticated-orcid":false,"given":"Lewan","family":"Parker","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity 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