{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:24:27Z","timestamp":1791170667593,"version":"4.1.0"},"reference-count":73,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:p> Abnormal microRNA (miRNA) expression profiles have recently been associated with sporadic pituitary adenomas, suggesting that miRNAs can contribute to tumor formation; miRNAs are small noncoding RNAs that inhibit posttranscriptional expression of target mRNAs by binding to target sequences usually located in the 3\u2032-UTR. In this study, we investigated the role played by miR-107, a miRNA associated with different human cancers, in sporadic pituitary adenomas and its interaction with the pituitary tumor suppressor gene aryl hydrocarbon receptor-interacting protein ( AIP). miR-107 expression was evaluated in pituitary adenoma and normal pituitary samples using microRNA screen TLDA (TaqMan Low-Density Array) and RT-qPCR assays. We show that miR-107 expression was significantly upregulated in GH-secreting and nonfunctioning pituitary adenomas. We found that human AIP-3\u2032-UTR is a target of miR-107 since miR-107 inhibited in vitro AIP expression to 53.9 \u00b1 2% of the miRNA control in a luciferase assay and reduced endogenous AIP mRNA expression to 53 \u00b1 22% of the miRNA control in human cells. However, we did not observe a negative correlation between AIP and miR-107 expression in the human tumor samples. Furthermore, we show that miR-107 overexpression inhibited cell proliferation in human neuroblastoma and rat pituitary adenoma cells. In conclusion, miR-107 is overexpressed in pituitary adenomas and may act as a tumor suppressor. We have identified and confirmed AIP as a miR-107 target gene. Expression data in human samples suggest that the expression of AIP and miR-107 could be influenced by a combination of tumorigenic factors as well as compensatory mechanisms stimulated by the tumorigenic process. <\/jats:p>","DOI":"10.1152\/ajpendo.00546.2011","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T04:10:50Z","timestamp":1342671050000},"page":"E708-E719","source":"Crossref","is-referenced-by-count":69,"title":["MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro"],"prefix":"10.1152","volume":"303","author":[{"given":"Giampaolo","family":"Trivellin","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom;"},{"name":"Endocrinology Division, Department of Medical and Surgical Sciences, Via Ospedale, Padua, 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