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Plasma growth hormone (GH) concentrations and major secretory bursts were characterized. Insulin-like growth factor I (IGF-I) was evaluated as an integrative marker of peripheral GH effector activity. Prolactin (PRL) was assessed by basal concentrations and by stimulating the pituitary with exogenous thyrotropin-releasing hormone. Leptin was studied for its linkage to metabolic signs of sleep loss and its correspondence to altered neuroendocrine regulation in other disease states. Last, plasma corticosterone was measured to investigate the degree of hypothalamic-pituitary-adrenal activation. Sleep deprivation was produced by the disk-over-water method, a well-established means of selective deprivation of sleep and noninterference with normal waking behaviors. Hormone concentrations were determined in sham comparisons and at intervals during baseline and experimental periods lasting at least 15 days in partially and totally sleep-deprived rats. The results indicate that high-amplitude pulses of GH were nearly abolished and that concentrations of GH, IGF-I, PRL, and leptin all were suppressed by sleep deprivation. Corticosterone concentration was relatively unaffected. Features of these results, such as low GH and low IGF-I, indicate failed negative feedback and point to hypothalamic mechanisms as containing the foci responsible for peripheral signs. <\/jats:p>","DOI":"10.1152\/ajpendo.00553.2003","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T01:13:15Z","timestamp":1076980395000},"page":"E1060-E1070","source":"Crossref","is-referenced-by-count":164,"title":["Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats"],"prefix":"10.1152","volume":"286","author":[{"given":"Carol A.","family":"Everson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/382250a0"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6474.1029"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-2-882"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04091-X"},{"key":"R5","unstructured":"Ben-Jonathan N, Mershon JL, Allen DL, and Steinmetz RW. 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