{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:30:58Z","timestamp":1759962658217},"reference-count":34,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:p>To determine the effects of an increase in lipolysis on the glycogenolytic effect of epinephrine (EPI), the catecholamine was infused portally into 18-h-fasted conscious dogs maintained on a pancreatic clamp in the presence [portal (Po)-EPI+FFA, n = 6] and absence (Po-EPI+SAL, n = 6) of peripheral Intralipid infusion. Control groups with high glucose (70% increase) and free fatty acid (FFA; 200% increase; HG+FFA, n = 6) and high glucose alone (HG+SAL, n = 6) were also included. Hepatic sinusoidal EPI levels were elevated (\u0394568 \u00b1 77 and \u0394527 \u00b1 37 pg\/ml, respectively) in Po-EPI+SAL and EPI+FFA but remained basal in HG+FFA and HG+SAL. Arterial plasma FFA increased from 613 \u00b1 73 to 1,633 \u00b1 101 and 746 \u00b1 112 to 1,898 \u00b1 237 \u03bcmol\/l in Po-EPI+FFA and HG+FFA but did not change in EPI+SAL or HG+SAL. Net hepatic glycogenolysis increased from 1.5 \u00b1 0.3 to 3.1 \u00b1 0.4 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>( P &lt; 0.05) by 30 min in response to portal EPI but did not rise (1.8 \u00b1 0.2 to 2.1 \u00b1 0.3 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>) in response to Po-EPI+FFA. Net hepatic glycogenolysis decreased from 1.7 \u00b1 0.2 to 0.9 \u00b1 0.2 and 1.6 \u00b1 0.2 to 0.7 \u00b1 0.2 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>by 30 min in HG+FFA and HG+SAL. Hepatic gluconeogenic flux to glucose 6-phosphate increased from 0.6 \u00b1 0.1 to 1.2 \u00b1 0.1 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>( P &lt; 0.05; by 3 h) and 0.7 \u00b1 0.1 to 1.6 \u00b1 0.1 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>( P &lt; 0.05; at 90 min) in HG+FFA and Po-EPI+FFA. The gluconeogenic parameters remained unchanged in the Po-EPI+SAL and HG+SAL groups. In conclusion, increased FFA markedly changed the mechanism by which EPI stimulated hepatic glucose production, suggesting that its overall lipolytic effect may be important in determining its effect on the liver.<\/jats:p>","DOI":"10.1152\/ajpendo.00565.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:41:39Z","timestamp":1425411699000},"page":"E291-E301","source":"Crossref","is-referenced-by-count":22,"title":["Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs"],"prefix":"10.1152","volume":"284","author":[{"given":"Chang An","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Galassetti","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and 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