{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:07:18Z","timestamp":1790784438200,"version":"4.1.0"},"reference-count":25,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:p>We determined if blocking transmission in the fibers of the vagus nerves would affect basal hepatic glucose metabolism in the 18-h-fasted conscious dog. A pancreatic clamp (somatostatin, basal portal insulin, and glucagon) was employed. A 40-min control period was followed by a 90-min test period. In one group, stainless steel cooling coils (Sham, n = 5) were perfused with a 37\u00b0C solution, while in the other (Cool, n = 6), the coils were perfused with \u221220\u00b0C solution. Vagal blockade was verified by heart rate change (80 \u00b1 9 to 84 \u00b1 14 beats\/min in Sham; 98 \u00b1 12 to 193 \u00b1 22 beats\/min in Cool). The arterial glucose level was kept euglycemic by glucose infusion. No change in tracer-determined glucose production occurred in Sham, whereas in Cool it dropped significantly (2.4 \u00b1 0.4 to 1.9 \u00b1 0.4 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>). Net hepatic glucose output did not change in Sham but decreased from 1.9 \u00b1 0.3 to 1.3 \u00b1 0.3 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>in the Cool group. Hepatic gluconeogenesis did not change in either group. These data suggest that vagal blockade acutely modulates hepatic glucose production by inhibiting glycogenolysis.<\/jats:p>","DOI":"10.1152\/ajpendo.00566.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:50:01Z","timestamp":1425412201000},"page":"E958-E964","source":"Crossref","is-referenced-by-count":21,"title":["Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs"],"prefix":"10.1152","volume":"283","author":[{"given":"Sylvain","family":"Cardin","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics,"},{"name":"Department of Neuroscience, Pro-Neuron, Gaithersburg, Maryland 20877"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Walmsley","sequence":"additional","affiliation":[{"name":"Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doss W.","family":"Neal","sequence":"additional","affiliation":[{"name":"Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Cherrington","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics,"},{"name":"Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.3.558"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.5.1198"},{"key":"B3","first-page":"229","volume":"36","author":"Chiasson JL","year":"1977","journal-title":"Fed Proc"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.271.1.E127"},{"key":"B5","first-page":"445","volume":"19","author":"DeBodo RC","year":"1963","journal-title":"Recent Prog Horm Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1994.266.3.E467"},{"key":"B7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/clinchem\/20.4.411","volume":"20","author":"Farmer RW","year":"1974","journal-title":"Clin Chem"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90026-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.6.672"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.6.E1178"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/clinchem\/24.10.1724","volume":"24","author":"Lloyd B","year":"1978","journal-title":"Clin Chem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.2.E400"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216204"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115342"},{"key":"B15","first-page":"415","volume":"257","author":"Morgan CR","year":"1963","journal-title":"Am J Med Sci"},{"key":"B16","first-page":"315","volume":"332","author":"Niijima A.","year":"1982","journal-title":"J Physiol (Paris)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90142-X"},{"key":"B18","first-page":"164","volume":"2","author":"Niijima A","year":"1987","journal-title":"News Physiol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(71)90089-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3703.1607"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.11.1594"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.260.3.E363"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00254-8"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.2.E194"},{"key":"B25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/ajplegacy.1957.189.1.43","volume":"189","author":"Wall JS","year":"1957","journal-title":"Am J Physiol"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00566.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T13:19:24Z","timestamp":1598793564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00566.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11,1]]}},"alternative-id":["10.1152\/ajpendo.00566.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00566.2001","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,1]]}}}