{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:15:48Z","timestamp":1763140548899},"reference-count":63,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:p>We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic \u03b2-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and alterations in skeletal muscle lipids of growth-restricted male rats occurs following early exercise training. Bilateral uterine vessel ligation performed on day 18 of gestation resulted in Restricted offspring born small ( P &lt; 0.05) compared with both sham-operated Controls and a sham-operated Reduced litter group. Offspring remained sedentary or underwent treadmill running from 5\u20139 (early exercise) or 20\u201324 (later exercise) wk of age. At 24 wk of age, Restricted and Reduced litter offspring had lower ( P &lt; 0.05) skeletal muscle peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 (PGC-1\u03b1) protein expression compared with Control offspring. Early exercise training had the expected effect of increasing skeletal muscle markers of mitochondrial biogenesis, but, at this early age (9 wk), there was no deficit in Restricted and Reduced litter skeletal muscle mitochondrial biogenesis. Unlike our previous observations in pancreatic \u03b2-cell mass, there was no \u201creprogramming\u201d effect of early exercise on adult skeletal muscle such that PGC-1\u03b1 was lower in adult Restricted and Reduced litter offspring irrespective of exercise training. Later exercise training increased mitochondrial biogenesis in all groups. In conclusion, although the response to exercise training remains intact, early exercise training in rats born small does not have a reprogramming effect to prevent deficits in skeletal muscle markers of mitochondrial biogenesis in adulthood.<\/jats:p>","DOI":"10.1152\/ajpendo.00583.2011","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T06:51:01Z","timestamp":1329893461000},"page":"E1221-E1230","source":"Crossref","is-referenced-by-count":20,"title":["Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1\u03b1 in adulthood"],"prefix":"10.1152","volume":"302","author":[{"given":"Rhianna C.","family":"Laker","sequence":"first","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Parkville, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Wlodek","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of 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