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By means of MALDI-TOF MS technique, we genotyped an expanded single nucleotide polymorphism panel, including the CAPN10 UCSNP-44, -43, -56, ins\/del-19, -110, -58, -63, and -22 in a sample of 146 German PCOS women and 606 population-based controls. Statistical analysis revealed an association between UCSNP-56 and susceptibility to PCOS with an odds ratio (OR) of 2.91 (95% CI = 1.51\u20135.61) for women carrying an AA genotype compared with GG. As expected, the 22-genotype of the ins\/del-19 variant, which is in high linkage disequilibrium ( r<jats:sup>2<\/jats:sup>= 0.98) with UCSNP-56, was also significantly associated (OR = 2.98, 95% CI = 1.55\u20135.73). None of the additionally tested variants alone showed any significant association with PCOS. A meta-analysis including our study (altogether 623 PCOS cases and 1,224 controls) also showed significant association only with ins\/del-19. The most common haplotype TGG3AGCA was significantly associated with a lower risk for PCOS (OR = 0.487, P = 0.0057). In contrast, the TGA2AGCA haplotype was associated with an increased risk for PCOS (OR = 3.557, P = 0.0011). By investigating a broad panel of CAPN10 variants, our results pointed to an allele dose-dependent association of UCSNP-56 and ins\/del-19 with PCOS.<\/jats:p>","DOI":"10.1152\/ajpendo.00584.2005","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T23:08:43Z","timestamp":1163632123000},"page":"E836-E844","source":"Crossref","is-referenced-by-count":25,"title":["Calpain-10 variants and haplotypes are associated with polycystic ovary syndrome in 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