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As a result, multiple members of the Reg family genes (Reg2, -3\u03b1, and -3\u03b2, previously not known to promote islet cell growth) were significantly upregulated in the pancreas. This finding was subsequently confirmed by Northern blot and\/or real-time PCR, which exhibited 2- to 8-fold increases in the levels of these mRNAs. Interestingly, these Reg family genes were also activated after streptozotocin-induced \u03b2-cell damage and diabetes (wild-type T1D mice) when islet cells were undergoing regeneration. Immunohistochemistry revealed increased Reg proteins in exocrine as well as endocrine pancreas and suggested their potential role in \u03b2-cell neogenesis in PID or T1D mice. Previously, other Reg proteins (Reg1 and islet neogenesis-associated protein) have been shown to promote islet cell replication and neogenesis. These uncharacterized Reg proteins may play a similar but more potent role, not only in normal islet cell growth in PID mice, but also in islet cell regeneration after T1D.<\/jats:p>","DOI":"10.1152\/ajpendo.00596.2005","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T03:33:11Z","timestamp":1138764791000},"page":"E50-E58","source":"Crossref","is-referenced-by-count":47,"title":["Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse 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