{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:58:58Z","timestamp":1780394338960,"version":"3.54.1"},"reference-count":27,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:p>Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing \u03b1-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the \u03b1-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized \u03b1-cell line \u03b1TC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the \u03b2-cell line INS 832\/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the \u03b1-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between \u03b1-cells and \u03b2-cells in the endocrine pancreas, leading to attenuation in insulin secretion.<\/jats:p>","DOI":"10.1152\/ajpendo.00599.2013","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T03:34:08Z","timestamp":1397619248000},"page":"E1257-E1263","source":"Crossref","is-referenced-by-count":19,"title":["Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic \u03b1-cell"],"prefix":"10.1152","volume":"306","author":[{"given":"Alison S.","family":"Salvatori","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollisa M.","family":"Elrick","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willis K.","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Corbett","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L. 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