{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:45:00Z","timestamp":1771627500392,"version":"3.50.1"},"reference-count":19,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:p> Short-term exposure to glucose increases insulin secretion during subsequent stimulation. This priming effect of glucose was further investigated in the perfused rat pancreas. A 5-min pulse of 27.7 mM glucose enhanced the response to a second pulse of the sugar after a 5- or 30-min period of 3.9 mM glucose. With a 10-min pulse of 27.7 mM glucose, the priming effect tended to persist also after a 60-min but not after a 90-min rest period. The priming effects of glucose were also evaluated from enhancement of stimulation 15 min later with 3-isobutyl-l-methylxanthine (IBMX). A 10-min pulse of 8.3 and 27.7, but not 5.6 mM glucose enhanced IBMX-induced insulin secretion. Cycloheximide did not abolish the priming effect of glucose on IBMX-induced insulin secretion. Conclusions are 1) priming is rapidly induced; 2) it persists longer than the time of induction; 3) threshold concentrations of glucose that induce priming are similar to those that initiate insulin secretions; and 4) mechanisms causing priming may not involve protein synthesis. <\/jats:p>","DOI":"10.1152\/ajpendo.1981.240.1.e24","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:03:02Z","timestamp":1513872182000},"page":"E24-E31","source":"Crossref","is-referenced-by-count":13,"title":["Time and dose dependencies for priming effect of glucose on insulin secretion"],"prefix":"10.1152","volume":"240","author":[{"given":"V.","family":"Grill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.2.S538"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0930054"},{"key":"p_3","first-page":"73","volume":"1","author":"CERASI E","year":"1975","journal-title":"Diabkte Metab."},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0790483"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1974.tb02345.x"},{"key":"p_6","first-page":"295","author":"COORE H. G.","year":"1964","journal-title":"Pergamon"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109002"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-105-4-980"},{"key":"p_9","first-page":"1","volume":"32","author":"GRODSKY G. M","year":"1975","journal-title":"Hand. Exp. Pharmacol."},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-10-1375"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-4-1003"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221631"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.1.27"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1139\/y69-133"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.2.S555"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1210\/endo-93-5-1001"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108194"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.2337\/diab.22.5.354"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1093499"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1981.240.1.E24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T12:05:13Z","timestamp":1567944313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1981.240.1.E24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1,1]]}},"alternative-id":["10.1152\/ajpendo.1981.240.1.E24"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1981.240.1.e24","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1,1]]}}}