{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T01:10:19Z","timestamp":1660180219023},"reference-count":22,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1981,2,1]]},"abstract":"<jats:p>Heptic glycolytic and gluconeogenic intermediates from fasted newborns of five control and five 3-day starved canine mothers (MCS) were studied at 0, 3, 6, 9, and 24 h of age. MCS did not affect fetal hepatic glycogen concentration; however, a significant increase in uridine diphosphate glucose (UDPG) (0.186 vs. 0.106 mumol\/g), fructose 6-phosphate (0.084 vs. 0.034), pyruvate (0.321 vs. 0.126), and citrate (0.190 vs. 0.140) concentrations occurred. At 3 h, the intrahepatic glucose concentration among the MCS newborns declined (3.09 vs. 6.34) and remained lower than the controls for up to 9 h. UDPG concentration, however, remained elevated throughout the 24 h. In addition intrahepatic pyruvate was significantly elevated in the MCS group. Elevated phosphoenolpyruvate concentrations were observed between 3 and 6 h. Malate levels were lower than controls between 6 and 9 h and alpha-ketoglutarate was significantly higher between 6 and 24 h. Calculated cytoplasmic NAD\/NADH ratio was elevated throughout the 24 h. Hepatic triglycerides were higher than controls up to 9 h. A decline in hepatic triglycerides was observed between 9 and 24 h. The results suggest increased glycolysis and suppressed gluconeogenesis in the MCS puppies, probably because of increased triglyceride synthesis and decreased free fatty acid oxidation resulting in a lack of cytoplasmic NADH.<\/jats:p>","DOI":"10.1152\/ajpendo.1981.240.2.e88","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T21:04:17Z","timestamp":1513890257000},"page":"E88-E94","source":"Crossref","is-referenced-by-count":0,"title":["Effect of maternal canine starvation on fetal and neonatal liver metabolism"],"prefix":"10.1152","volume":"240","author":[{"given":"E. L.","family":"Miettinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"p_2","first-page":"1404","volume":"3","author":"BERGMEYER H. U","year":"1974","journal-title":"Academic"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJM197408152910702","volume":"291","author":"BOYD R. 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