{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T05:33:39Z","timestamp":1648877619999},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1990,2,1]]},"abstract":"<jats:p> The toothless (tl) rat is a nonlethal osteopetrotic mutation characterized by systemic skeletal sclerosis, growth plate morphology suggestive of rickets, and morphological evidence of reduced osteoclastic bone resorption. Vitamin D metabolites, serum calcium and phosphorus levels, and the developmental appearance of vitamin D-dependent intestinal calcium binding protein (calbindin-D9k) was studied in normal and mutant rats of tl stock from 7 to 35 days of age. 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] was found to be significantly elevated in mutant animals by 7 days of age (71 +\/- 9 pM, tl\/tl vs. 24 +\/- 8 pM, +\/?) and continued to increase to a peak of 428 pM at the time of weaning. This was 240% higher than normals at this period. The elevated levels of 1,25-(OH)2D3 stimulated a significant and precocious appearance of intestinal calbindin-D9k in mutants, beginning by 14 days of age and reaching their peak levels at 21 days postpartum (25.6 +\/- 1.7 micrograms\/mg protein, tl\/tl vs. 16.4 +\/- 1.5 micrograms\/mg protein, +\/?). The cause of the elevated circulating levels of 1,25-(OH)2D3 in tl rats is unknown but may be due to the low serum phosphorus levels present in these animals. <\/jats:p>","DOI":"10.1152\/ajpendo.1990.258.2.e377","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T04:36:45Z","timestamp":1513917405000},"page":"E377-E381","source":"Crossref","is-referenced-by-count":0,"title":["Elevated 1,25-dihydroxyvitamin D3 and intestinal calbindin-D9k in the toothless rat"],"prefix":"10.1152","volume":"258","author":[{"given":"M. F.","family":"Seifert","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of South Dakota School of Medicine,Vermillion 57069."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of South Dakota School of Medicine,Vermillion 57069."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of South Dakota School of Medicine,Vermillion 57069."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1990.258.2.E377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:03:04Z","timestamp":1567962184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1990.258.2.E377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2,1]]}},"alternative-id":["10.1152\/ajpendo.1990.258.2.E377"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1990.258.2.e377","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2,1]]}}}