{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T14:00:26Z","timestamp":1722261626971},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1990,5,1]]},"abstract":"<jats:p> The present investigation was undertaken to study whether, in human infection of varying severity, peripheral 3-methylhistidine efflux and urinary excretion are associated with net protein degradation and to estimate the protein synthesis rate from the combined effluxes of 3-methylhistidine, tyrosine, and phenylalanine. Quadruplicate femoral arteriovenous differences of 3-methylhistidine, tyrosine, and phenylalanine were multiplied by leg plasma flow in 15 infected patients. Leg effluxes for 3-methylhistidine, tyrosine, and phenylalanine were -0.074 +\/- 0.011, -2.57 +\/- 0.43, and -3.17 +\/- 0.44 mumol\/min, respectively. There was a significant linear relationship (P less than 0.01) between the effluxes of tyrosine and phenylalanine and the efflux and urinary excretion of 3-methylhistidine. A significant release of tyrosine and phenylalanine was observed in patients studied at the 3-methylhistidine level seen in normal healthy subjects. It is concluded that in infection 1) there is an increased breakdown of skeletal muscle protein and a reduced rate of protein synthesis, with the latter being relatively more important in patients with mild disease; and 2) urinary 3-methylhistidine excretion is associated with net skeletal muscle protein degradation for the patient group studied. <\/jats:p>","DOI":"10.1152\/ajpendo.1990.258.5.e856","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T04:24:58Z","timestamp":1513916698000},"page":"E856-E863","source":"Crossref","is-referenced-by-count":3,"title":["Total and net muscle protein breakdown in infection determined by amino acid effluxes"],"prefix":"10.1152","volume":"258","author":[{"given":"J.","family":"Sjolin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University Hospital, Uppsala,Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Stjernstrom","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University Hospital, Uppsala,Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Friman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University Hospital, Uppsala,Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University Hospital, Uppsala,Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wahren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University Hospital, Uppsala,Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1990.258.5.E856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:01:32Z","timestamp":1567962092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1990.258.5.E856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,5,1]]}},"alternative-id":["10.1152\/ajpendo.1990.258.5.E856"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1990.258.5.e856","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5,1]]}}}