{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:46:07Z","timestamp":1780433167521,"version":"3.54.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p> To investigate whether changes in systemic pH influence ketone body production or utilization, total ketone body (TK) kinetics were measured with [3-14C]acetoacetate and D-beta-[1,3-13C2]hydroxybutyrate tracers in overnight fasted subjects during metabolic alkalosis (NaHCO3 infusion) or acidosis [NH4Cl ingestion or arginine (Arg)-HCl infusion]. Somatostatin, with insulin, glucagon, and growth hormone replacement, was infused in all studies. Blood pH and HCO3- (mM) increased from baseline (0-30 min) to 180-210 min by 0.08 +\/- 0.02 and 7 +\/- 1 with NaHCO3 and decreased by 0.08 +\/- 0.2 and 7 +\/- 1 or 5 +\/- 1 with NH4Cl or Arg-HCl (all P less than 0.005). Over this period blood TK (microM) differed between the NaHCO3 (+198 +\/- 65) and both NH4Cl (-90 +\/- 53) and Arg-HCl (-154 +\/- 55) (P less than 0.05). These changes resulted from parallel alterations in TK production rate of appearance (Ra TK, mumol.kg-1.min-1), because changes from baseline in Ra 14C TK also differed between NaHCO3 (+1.9 +\/- 0.8) and NH4Cl (-1.0 +\/- 0.6) and Arg-HCl (-2.0 +\/- 0.5) (P less than 0.05). Ra TK calculated with single- or dual-tracer techniques were similar. Blood free fatty acids (FFA) increased with NaHCO3, and FFA and glycerol decreased with NH4Cl and Arg-HCl, suggesting that FFA availability mediated the pH effects on hepatic ketogenesis. These results demonstrate that modest changes in systemic pH modify FFA availability and TK production rates. <\/jats:p>","DOI":"10.1152\/ajpendo.1990.259.3.e327","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:38:52Z","timestamp":1514180332000},"page":"E327","source":"Crossref","is-referenced-by-count":4,"title":["Systemic pH modifies ketone body production rates and lipolysis in humans."],"prefix":"10.1152","volume":"259","author":[{"given":"V L","family":"Hood","sequence":"first","affiliation":[{"name":"College of Medicine, University of Vermont, Burlington 05405."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Keller","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Vermont, Burlington 05405."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"Haymond","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Vermont, Burlington 05405."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"K\u00fcry","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Vermont, Burlington 05405."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1990.259.3.E327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:49:09Z","timestamp":1568008149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1990.259.3.E327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1152\/ajpendo.1990.259.3.E327"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1990.259.3.e327","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}