{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:14:57Z","timestamp":1771643697183,"version":"3.50.1"},"reference-count":34,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1992,5,1]]},"abstract":"<jats:p> To determine the effects of the presence of insulin in poorly controlled diabetes, depancreatized (PX) dogs (n = 5) were studied during rest and 150 min of exercise in paired experiments in which saline alone was infused (IDEF) and in which insulin was replaced intraportally (200 microU.kg-1.min-1) with glucose clamped at the levels in IDEF (IR+G). PX dogs (n = 4) were also studied with insulin, but glucose was allowed to fall (IR). Insulin was not detectable, 6 +\/- 1 and 6 +\/- 2 microU\/ml in IDEF, IR+G, and IR. Plasma glucose was 470 +\/- 47, 480 +\/- 48, and 372 +\/- 35 mg\/dl at rest in IDEF, IR+G, and IR, respectively. Levels were unchanged with exercise in IDEF and IR+G, but fell by 139 +\/- 13 mg\/dl in IR. Basal glucose rate of appearance (Ra) was 7.0 +\/- 0.9, 1.3 +\/- 1.1, and 6.0 +\/- 0.7 mg.kg-1.min-1 in IDEF, IR+G, and IR, respectively. Exercise elicited a rise in Ra in only IDEF. The rises in Rd and metabolic clearance rate in IDEF were reduced (delta 2.6 +\/- 0.7 and delta 0.8 +\/- 0.3 ml.kg-1.min-1 at 150 min) compared with IR+G (delta 5.3 +\/- 1.9 and delta 1.7 +\/- 0.2 ml.kg-1.min-1 at 150 min) and IR (delta 3.7 +\/- 1.2 and delta 2.4 +\/- 0.8 ml.kg-1.min-1). The insulin sensitivity of glucose utilization (Rd) was elevated by approximately 75% at 150 min. Basal glycerol was similar in IDEF and IR but was reduced by approximately 70% in IR+G. Glycerol rose similarly with exercise in IDEF and IR.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/ajpendo.1992.262.5.e574","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:05:43Z","timestamp":1513897543000},"page":"E574-E582","source":"Crossref","is-referenced-by-count":6,"title":["Glucoregulation during rest and exercise in depancreatized dogs: role of the acute presence of insulin"],"prefix":"10.1152","volume":"262","author":[{"given":"D. H.","family":"Wasserman","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, VanderbiltUniversity School of Medicine, Nashville, Tennessee 37232."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Bupp","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, VanderbiltUniversity School of Medicine, Nashville, Tennessee 37232."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, VanderbiltUniversity School of Medicine, Nashville, Tennessee 37232."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bracy","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, VanderbiltUniversity School of Medicine, Nashville, Tennessee 37232."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Lacy","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, VanderbiltUniversity School of Medicine, Nashville, Tennessee 37232."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196906000-00008"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BF01223279"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-6-1-45"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113517"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114742"},{"key":"p_10","first-page":"E129","author":"Challiss R. A. J.","year":"1989","journal-title":"Metab. 19)"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(71)90098-9"},{"key":"p_12","first-page":"E362","author":"Davis M. A.","year":"1984","journal-title":"Metab. 10)"},{"key":"p_13","first-page":"445","volume":"19","author":"Debodo R. D.","year":"1963","journal-title":"Recent Prog. Harm. Res."},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610010405"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.6.869"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108645"},{"key":"p_18","first-page":"E428","author":"Kemmer F. W.","year":"1982","journal-title":"Metab. 5)"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216204"},{"key":"p_21","first-page":"415","volume":"257","author":"Morgan C. R.","year":"1963","journal-title":"Am. J. Med. Sci."},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.003543"},{"key":"p_23","first-page":"E84","author":"Radziuk J.","year":"1978","journal-title":"Metab. Gastrointest. Physiol. 3)"},{"key":"p_24","first-page":"E630","author":"Rizza R. A.","year":"1981","journal-title":"Metab. 3)"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(76)90091-3"},{"key":"p_26","doi-asserted-by":"crossref","first-page":"22A","DOI":"10.2337\/diacare.39.1.22","volume":"39","author":"Shi Z.","year":"1990","journal-title":"Diabetes"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111371"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108275"},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1210\/endo-85-1-165"},{"key":"p_30","volume":"260","author":"Wasserman D. H.","journal-title":"J. 0. Hill, and N. N. Abumrad. Interaction of exercise and insulin action in man. Am. J. Physiol."},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.4.484"},{"key":"p_32","first-page":"E500","author":"Wasserman D. H.","year":"1989","journal-title":"Metab. 19)"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.4.1272"},{"key":"p_36","first-page":"89","author":"Annu","year":"1990","journal-title":"Meet. Endocr. Sot. 72nd AtZanta GA."},{"key":"p_37","first-page":"E424","author":"Lickley H. L. A.","year":"1983","journal-title":"Metab. 8)"},{"key":"p_38","first-page":"1724","volume":"24","author":"Lloyd B.","year":"1978","journal-title":"CZin. Chem."},{"key":"p_39","first-page":"E428","author":"Moates J. M.","year":"1988","journal-title":"Metab. 18)"},{"key":"p_40","first-page":"E108","author":"Wasserman D. H.","year":"1989","journal-title":"Metab. 20)"},{"key":"p_41","first-page":"E382","author":"Wolfe R. R.","year":"1990","journal-title":"Metab. 21)"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-4-641"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1992.262.5.E574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:19:15Z","timestamp":1567959555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1992.262.5.E574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5,1]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,5,1]]}},"alternative-id":["10.1152\/ajpendo.1992.262.5.E574"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1992.262.5.e574","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5,1]]}}}