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One of the analogues, D-Tpi6,Leu13-psi (CH2NH)Leu14-bombesin-(6-14) (RC-3095), was injected into the lateral brain ventricle just preceding intracerebroventricular administration of GRP-(14-27) to evaluate its antagonistic effect on GRP-induced serum growth hormone (GH) suppression. Analogues RC-3095, D-Trp6,Leu13-psi (CH2NH)Leu14-bombesin-(6-14) (RC-3125), and D-Trp6,Leu13-psi (CH2NH)Phe14-bombesin-(6-14) (RC-3420), but not D-Tpi6,Leu13-psi (CH2NH)Phe14-bombesin-(6-14) (RC-3105), significantly (P &lt; 0.01) inhibited GRP-(14-27)-stimulated serum gastrin secretion. Analogues RC-3095, RC-3420, and RC-3105, but not RC-3125, demonstrated significant (P &lt; 0.05) antagonistic activities on GRP-(14-27)-stimulated plasma glucagon secretion. Intracerebroventricular injection of RC-3095 (10 micrograms) immediately before GRP-(14-27) (1 microgram) completely prevented the GRP-(14-27)-induced serum GH suppression. These results indicate that 1) marked differences exist in the ability of these analogues to antagonize GRP-(14-27)-induced gastrin or glucagon release, suggesting the existence of different bombesin\/GRP receptor subtypes, and 2) the central effect of bombesin\/GRP on GH release from the pituitary is probably mediated through specific bombesin\/GRP receptors.<\/jats:p>","DOI":"10.1152\/ajpendo.1992.263.4.e712","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:44:22Z","timestamp":1513899862000},"page":"E712-E717","source":"Crossref","is-referenced-by-count":0,"title":["Endocrine effects of new bombesin\/gastrin-releasing peptide antagonists in rats"],"prefix":"10.1152","volume":"263","author":[{"given":"J.","family":"Pinski","sequence":"first","affiliation":[{"name":"Endocrine, Polypeptide and Cancer Institute, Department of VeteransAffairs Medical Center, New Orleans, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yano","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide and Cancer Institute, Department of VeteransAffairs Medical Center, New Orleans, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Groot","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide and Cancer Institute, Department of VeteransAffairs Medical Center, New Orleans, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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