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In cells from the other tumors, AVP triggered different patterns of [Ca2+]i rise, which consisted of low-amplitude slow monophasic increases at low AVP concentration and a high-amplitude spike increase followed by a sustained plateau (spike-plateau pattern) at higher concentration of AVP. Slow monophasic increases and the spike of spike-plateau responses were due to calcium release from internal stores, whereas the plateau was a consequence of calcium entry. These two patterns (transient vs. spike-plateau) resemble those observed in subpopulations of corticotrophs from healthy rat pituitary glands (Corcuff et al., J. Biol. Chem. 268: 22313-22321, 1993), suggesting that tumorigenesis can lead in pituitary tissues to a selection rather than alteration of AVP [Ca2+]i signals.<\/jats:p>","DOI":"10.1152\/ajpendo.1995.269.3.e451","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T09:38:21Z","timestamp":1513935501000},"page":"E451-E457","source":"Crossref","is-referenced-by-count":0,"title":["Tumor-related selection of calcium signals in vasopressin-stimulated human adenomatous corticotrophs"],"prefix":"10.1152","volume":"269","author":[{"given":"J. B.","family":"Corcuff","sequence":"first","affiliation":[{"name":"Laboratory of Neurophysiology, Universite de Bordeaux II,France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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