{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:38:58Z","timestamp":1791635938448,"version":"4.3.4"},"reference-count":23,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1996,3,1]]},"abstract":"<jats:p> A model describing beta-cell secretion during an oral glucose tolerance test (OGTT) is introduced. The aim was to quantify beta-cell activity in different pathologies by analyzing peripheral concentration data of insulin, C-peptide, and islet amyloid polypeptide (IAPP). Insulin appearance in periphery is given by the fraction of C-peptide secretion, CPS(t), which accounts for liver degradation. A novelty of this study is the inclusion of IAPP delivery assumed proportional to CPS(t). Although IAPP fractional clearance is estimated in every subject, the clearances of insulin and C-peptide are assigned from a wide set of previous independent studies. Sensitivity analysis was performed to quantify the \"error\" in the estimated variables due to these assignments. All parameters relating to beta-cell secretion increased in the glucose-intolerant states [integrated CPS(t)=56 +\/- 8 nmol\/l in 180 min vs. 32 +\/- 3 of controls, P&lt;0.05; total IAPP delivery= 83 +\/- 21 pmol\/l in 180 min vs. 41 +\/- 6, P&lt;0.05]. Elevated plasma IAPP concentration of the patients was due to augmented secretion since IAPP clearance was found to be even slightly greater than in controls, (0.053 +\/- 0.011 vs. 0.034 +\/- 0.004 min-1) and markedly lower than that of insulin (0.14 +\/- 0.02, P&lt;0.01). In conclusion, the model introduced here allows the characterization of beta-cell secretory parameters during a simple test such as OGTT. <\/jats:p>","DOI":"10.1152\/ajpendo.1996.270.3.e522","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T09:21:48Z","timestamp":1513934508000},"page":"E522-E531","source":"Crossref","is-referenced-by-count":21,"title":["Integrated mathematical model to assess beta-cell activity during the oral glucose test"],"prefix":"10.1152","volume":"270","author":[{"given":"K.","family":"Thomaseth","sequence":"first","affiliation":[{"name":"Institute of Systems Science, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kautzky-Willer","sequence":"additional","affiliation":[{"name":"Institute of Systems Science, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ludvik","sequence":"additional","affiliation":[{"name":"Institute of Systems Science, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Prager","sequence":"additional","affiliation":[{"name":"Institute of Systems Science, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pacini","sequence":"additional","affiliation":[{"name":"Institute of Systems Science, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110398"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610080204"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.2.223"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(88)90094-6"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610030202"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90966-9"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404025"},{"key":"p_10","first-page":"1304","volume":"41","author":"Kautzky-Willer A.","journal-title":"A&et& Clin. 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