{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T06:41:54Z","timestamp":1727073714055},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:p> Insulin action on adipocytes was studied in the offspring of mothers who had been fed either a control (20% protein) or a low (8%)-protein diet during pregnancy and lactation. Adipocytes isolated from low-protein offspring had significantly higher basal and insulin-stimulated glucose uptakes than controls. This may be related to a threefold increase in insulin receptors in low-protein adipocytes. Consistent with these observed changes in glucose transport, adipocytes from low-protein animals had significantly higher basal and insulin-stimulated insulin receptor substrate (IRS)-1-associated phosphatidylinositol 3-kinase (PI 3-kinase) activities. There was also more p85-associated PI 3-kinase activity in these adipocytes. There was no difference in expression in the p85 regulatory subunit or the p110-alpha catalytic subunit of PI 3-kinase. In contrast, there was a sixfold reduction in the p110-beta catalytic subunit of PI 3-kinase in adipocytes from low-protein animals. These results suggest that poor fetal nutrition during pregnancy and lactation can have long-term effects on glucose transport and on the expression of key components of the insulin signaling pathway in adipocytes. <\/jats:p>","DOI":"10.1152\/ajpendo.1997.273.1.e46","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T11:34:23Z","timestamp":1513942463000},"page":"E46-E51","source":"Crossref","is-referenced-by-count":33,"title":["Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes"],"prefix":"10.1152","volume":"273","author":[{"given":"S. E.","family":"Ozanne","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. T.","family":"Nave","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital,Cambridge, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.1997.273.1.E46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:00:05Z","timestamp":1567965605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.1997.273.1.E46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,7,1]]}},"alternative-id":["10.1152\/ajpendo.1997.273.1.E46"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.1997.273.1.e46","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7,1]]}}}