{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:48:04Z","timestamp":1789379284739,"version":"build-2803163510"},"reference-count":35,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:p>The tripeptide pyro-Glu-His-Pro-NH<jats:sub>2<\/jats:sub>[thyrotropin-releasing hormone (TRH)] was isolated from the hypothalamus as a thyrotropin-releasing factor. It has a broad spectrum of central nervous system-mediated actions, including the stimulation of exocrine pancreatic secretion. TRH is also synthesized in the endocrine pancreas and found in the systemic circulation. Enzymatic degradation of TRH in vivo produces other bioactive peptides such as cyclo(His-Pro). Because of the short half-life of TRH and the stability of cyclo(His-Pro) in vivo, we postulated that at least part of the peripheral TRH effects on the exocrine pancreatic secretion may be attributed to cyclo(His-Pro), which has been shown to have other biological activities. This study determines in parallel the peripheral effects of TRH and cyclo(His-Pro) as well as the putative contribution of other TRH-related peptides on exocrine pancreatic secretion in rats. TRH and its metabolite cyclo(His-Pro) dose dependently inhibited 2-deoxy-d-glucose (2-DG)-stimulated pancreatic secretion. TRH and all the related peptides tested had no effect on the basal and cholecystokinin-stimulated amylase release from pancreatic acinar cells in vitro. These data indicate that cyclo(His-Pro) mimics the peripheral inhibitory effect of TRH on 2-DG-stimulated exocrine pancreatic secretion. This effect is not detected on isolated pancreatic acini. Our findings provide a new biological contribution for cyclo(His-Pro) with potential experimental and clinical applications.<\/jats:p>","DOI":"10.1152\/ajpendo.1997.273.6.e1127","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T12:27:40Z","timestamp":1513945660000},"page":"E1127-E1132","source":"Crossref","is-referenced-by-count":3,"title":["A new biological contribution of cyclo(His-Pro) to the peripheral inhibition of pancreatic secretion"],"prefix":"10.1152","volume":"273","author":[{"given":"Pascal","family":"Fragner","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 30, M\u00e9canisme d\u2019Action Cellulaire des Hormones, H\u00f4pital Necker-Enfants-Malades, Tour Lavoisier, 75743 Paris Cedex 15;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Presset","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 410, Neuroendocrinologie et Biologie Cellulaire Digestives, 75870 Paris Cedex 18; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bernad","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique 5075, Universit\u00e9 de Montpellier I et II, Laboratoire des Aminopeptides, Peptides et Proteines, Facult\u00e9 de Pharmacie, 34060 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Martinez","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique 5075, Universit\u00e9 de Montpellier I et II, Laboratoire des Aminopeptides, Peptides et Proteines, Facult\u00e9 de Pharmacie, 34060 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Roze","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 410, Neuroendocrinologie et Biologie Cellulaire Digestives, 75870 Paris Cedex 18; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Aratan-Spire","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 30, M\u00e9canisme d\u2019Action Cellulaire des Hormones, H\u00f4pital Necker-Enfants-Malades, Tour Lavoisier, 75743 Paris Cedex 15;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91121-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-114-6-2369"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1979.tb13250.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/274174a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(69)90868-7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1979.tb02082.x"},{"key":"B7","first-page":"1371","volume":"130","author":"Ebiou J.-C.","year":"1992","journal-title":"Endocrinology"},{"key":"B8","first-page":"765","volume":"131","author":"Ebiou J.-C.","year":"1992","journal-title":"Endocrinology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110097"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-5-2501"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb46645.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-5-1292"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.3.7679984"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979980"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(82)90711-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-6-1059"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-6-2400"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.3079917"},{"key":"B19","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1016\/S0021-9258(18)48227-0","volume":"262","author":"Lignon M.","year":"1987","journal-title":"J. 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