{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:31:15Z","timestamp":1787988675341,"version":"build-2784847793"},"reference-count":37,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p> The acute effects of thyroid hormones on glucocorticoid secretion were studied. Venous blood samples were collected from male rats after they received intravenous 3,5,3\u2032-triiodothyronine (T<jats:sub>3<\/jats:sub>) or thyroxine (T<jats:sub>4<\/jats:sub>). Zona fasciculata-reticularis (ZFR) cells were treated with adrenocorticotropic hormone (ACTH), T<jats:sub>3<\/jats:sub>, T<jats:sub>4<\/jats:sub>, ACTH plus T<jats:sub>3<\/jats:sub>, or ACTH plus T<jats:sub>4<\/jats:sub> at 37\u00b0C for 2 h. Corticosterone concentrations in plasma and cell media, and also adenosine 3\u2032,5\u2032-cyclic monophosphate (cAMP) production in ZFR cells in the presence of 3-isobutyl-1-methylxanthine, were determined. The effects of thyroid hormones on the activities of steroidogenic enzymes of ZFR cells were measured by the amounts of intermediate steroidal products separated by thin-layer chromatography. Administration of T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> suppressed the basal and the ACTH-stimulated levels of plasma corticosterone. In ZFR cells, both thyroid hormones inhibited ACTH-stimulated corticosterone secretion, but the basal corticosterone was inhibited only with T<jats:sub>3<\/jats:sub>&gt;10<jats:sup>\u221210<\/jats:sup> M or T<jats:sub>4<\/jats:sub>&gt;10<jats:sup>\u22128<\/jats:sup> M. Likewise, T<jats:sub>3<\/jats:sub> or T<jats:sub>4<\/jats:sub> at 10<jats:sup>\u22127<\/jats:sup> M inhibited the basal- and ACTH-stimulated levels of intracellular cAMP. Physiological doses of T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> decreased the activities of 3\u03b2-hydroxysteroid dehydrogenase, 21-hydroxylase, and 11\u03b2-hydroxylase. These results suggest that thyroid hormones counteract ACTH in adrenal steroidogenesis through their inhibition of cAMP production in ZFR cells. <\/jats:p>","DOI":"10.1152\/ajpendo.1998.274.2.e238","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:11:39Z","timestamp":1513926699000},"page":"E238-E245","source":"Crossref","is-referenced-by-count":13,"title":["Acute effects of thyroid hormones on the production  of adrenal cAMP and corticosterone in male rats"],"prefix":"10.1152","volume":"274","author":[{"given":"Ming-Jae","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Mei","family":"Kau","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology, Fu-Jen Catholic University, Taipei 242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow-Chwen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chung","family":"Chiao","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann-Jong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Liaw","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu-Pian","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology, Fu-Jen Catholic University, Taipei 242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei 112, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Low-Tone","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei 112, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, National Yang-Ming University, Taipei 112;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.3.1324156"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(64)90084-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(82)90032-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000179504"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-5-2767"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/endo-74-4-509"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-84-3-692"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-34-6-919"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(93)90102-P"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90016-6"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-155"},{"key":"B13","first-page":"1302","volume":"11","author":"Jao J.","year":"1962","journal-title":"Metabolism"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-5-2567"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.9.113"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00768-N"},{"issue":"34","key":"B17","first-page":"E910","volume":"271","author":"Lu S.-S.","year":"1996","journal-title":"Am. 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