{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:10:06Z","timestamp":1790431806406,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p> The role of brown adipose tissue in total energy balance and cold-induced thermogenesis was studied. Mice expressing mitochondrial uncoupling protein 1 (UCP-1) from the fat-specific aP2 gene promoter (heterozygous and homozygous aP2 -Ucp transgenic mice) and their nontransgenic C57BL6\/J littermates were used. The transgenic animals are resistant to obesity induced by a high-fat diet, presumably due to ectopic synthesis of UCP-1 in white fat. These animals exhibited atrophy of brown adipose tissue, as indicated by smaller size of brown fat and reduction of its total UCP-1 and DNA contents. Norepinephrine-induced respiration (measured in pentobarbital sodium-anesthetized animals) was decreased proportionally to the dosage of the transgene, and the homozygous (but not heterozygous) transgenic mice exhibited a reduction in their capacity to maintain body temperature in the cold. Our results indicate that the role of brown fat in cold-induced thermogenesis cannot be substituted by increased energy expenditure in other tissues. <\/jats:p>","DOI":"10.1152\/ajpendo.1998.274.3.e527","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T12:11:06Z","timestamp":1513944666000},"page":"E527-E533","source":"Crossref","is-referenced-by-count":21,"title":["Brown fat is essential for cold-induced thermogenesis  but not for obesity resistance in aP2-<i>Ucp<\/i> mice"],"prefix":"10.1152","volume":"274","author":[{"given":"Bohum\u00edr","family":"Stefl","sequence":"first","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Janovsk\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Hodn\u00fd","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rossmeisl","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada","family":"Hor\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Syrov\u00fd","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslava","family":"B\u00e9mov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Bendlov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kopeck\u00fd","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Charles University, 128 00 Prague; Institute of Endocrinology, 116 91 Prague; and Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00755-2"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00384-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(94)90099-X"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/382622a0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/387090a0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1042\/bj2430281"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-269"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.5.900"},{"issue":"11","key":"B10","first-page":"E531","volume":"248","author":"Himms-Hagen J.","year":"1985","journal-title":"Am. 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