{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:57:12Z","timestamp":1774342632582,"version":"3.50.1"},"reference-count":19,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:p> To investigate the hypothesis that diabetes induces nephrogenic diabetes insipidus, we studied the urine-concentrating ability in response to vasopressin (AVP) in 12 patients with insulin-dependent diabetes mellitus (IDDM) and 12 nondiabetic controls. Subjects were euglycemic-clamped, and after oral water loading, AVP was infused intravenously for 150 min. AVP induced a greater ( P &lt; 0.001) rise in urine osmolality in controls (67.6 \u00b1 10.7 to 720 \u00b1 31.1 mosmol\/kg, P &lt; 0.001) than in IDDM patients (64.3 \u00b1 21.6 to 516.7 \u00b1 89.3 mosmol\/kg, P &lt; 0.001). Urinary aquaporin-2 concentrations after AVP infusion were higher in controls (611.8 \u00b1 105.6 fmol\/mg creatinine) than in IDDM (462.0 \u00b1 94.9 fmol\/mg creatinine, P = 0.003). Maximum urine osmolality in IDDM was inversely related to chronic blood glucose control, as indicated by Hb A<jats:sub>Ic<\/jats:sub> ( r = \u22120.87, P = 0.002). To test the hypothesis that improved glycemic control could reverse resistance to AVP, 10 IDDM subjects with poor glycemic control (Hb A<jats:sub>Ic<\/jats:sub> &gt;9%) were studied before ( B) and after ( A) intensified glycemic control. Maximum urine osmolality in response to AVP increased with improved glycemic control ( B, 443.8 \u00b1 49.0; A, 640.0 \u00b1 137.2 mosmol\/kg, P &lt; 0.001), and urinary aquaporin-2 concentrations after AVP increased from 112.7 \u00b1 69 to 375 \u00b1 280 fmol\/mg creatinine ( P = 0.006), with improved glycemic control. Poorly controlled IDDM is associated with reversible renal resistance to AVP. <\/jats:p>","DOI":"10.1152\/ajpendo.2000.279.1.e155","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T02:57:27Z","timestamp":1513911447000},"page":"E155-E160","source":"Crossref","is-referenced-by-count":17,"title":["Renal resistance to vasopressin in poorly controlled type 1 diabetes mellitus"],"prefix":"10.1152","volume":"279","author":[{"given":"K.","family":"McKenna","sequence":"first","affiliation":[{"name":"Beaumont Hospital, Dublin 9, Republic of Ireland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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