{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:40:55Z","timestamp":1793054455782,"version":"4.5.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:p> Induction of anesthesia is accompanied by modest hyperglycemia and a decreased plasma insulin concentration. Most insulin is secreted in discrete pulses occurring at \u223c6- to 8-min intervals. We sought to test the hypothesis that anesthesia inhibits insulin release by disrupting pulsatile insulin secretion in a canine model by use of direct portal vein sampling. We report that induction of anesthesia causes an abrupt decrease in the insulin secretion rate (1.1 \u00b1 0.2 vs. 0.7 \u00b1 0.1 pmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 min<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05) by suppressing insulin pulse mass (630 \u00b1 121 vs. 270 \u00b1 31 pmol, P &lt; 0.01). Anesthesia also elicited an \u223c30% higher increase in insulin pulse frequency ( P &lt; 0.01) and more orderly insulin concentration profiles ( P &lt; 0.01). These effects were evoked by either sodium thiamylal or nitrous oxide and isoflurane. In conclusion, anesthesia represses insulin secretion through the mechanism of a twofold blunting of pulse mass despite an increase in orderly pulse frequency. These data thus unveil independent amplitude and frequency controls of \u03b2-cells' secretory activity in vivo. <\/jats:p>","DOI":"10.1152\/ajpendo.2001.281.1.e93","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T18:23:06Z","timestamp":1513966986000},"page":"E93-E99","source":"Crossref","is-referenced-by-count":13,"title":["Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process"],"prefix":"10.1152","volume":"281","author":[{"given":"Stephen J.","family":"Vore","sequence":"first","affiliation":[{"name":"Department of Comparative Medicine, East Carolina School of Medicine, Greenville, North Carolina 27858;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Dale","family":"Aycock","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, East Carolina School of Medicine, Greenville, North Carolina 27858;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes D.","family":"Veldhuis","sequence":"additional","affiliation":[{"name":"Department of Medicine and National Science Foundation Center for Biological Timing, Charlottesville, Virginia 22908; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Butler","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/41.7.588"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1989.257.4.E479"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400849"},{"key":"B5","first-page":"267","volume":"27","author":"Camu F.","year":"1976","journal-title":"Acta Anaesthesiol Belg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.39.1.112"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/42.1.45"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.4.390"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198806000-00008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197405000-00008"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.401543"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1980.239.2.E150"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90021-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199007000-00013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-3-1098"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911083011903"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197411000-00002"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.6.855"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805123181902"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90723-H"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.5.E741"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.2083"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117310"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.12.1792"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.10.1317"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.6.E1043"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.269.3.E478"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107168"},{"key":"B29","first-page":"1792","volume":"32","author":"Porte D","year":"1973","journal-title":"Federation Proc"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197005000-00001"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009316"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.2.E218"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115893"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90269-X"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109750"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(77)80045-8"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90143-1"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.2001.281.1.E93","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:40:41Z","timestamp":1567968041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.2001.281.1.E93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["10.1152\/ajpendo.2001.281.1.E93"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.2001.281.1.e93","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,1]]}}}