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The rise in rates of protein degradation was accompanied by an increased activity of Ca<jats:sup>2+<\/jats:sup>-dependent proteolysis in both muscles, with no significant change in the activity of lysosomal and ATP-dependent proteolytic systems. In vitro rates of Ca<jats:sup>2+<\/jats:sup>-dependent proteolysis in soleus and EDL from normal rats decreased by \u223c35% in the presence of either 10<jats:sup>\u22125<\/jats:sup>M clenbuterol, a \u03b2<jats:sub>2<\/jats:sub>-adrenergic agonist, or epinephrine or norepinephrine. In the presence of dibutyryl cAMP, proteolysis was reduced by 62% in soleus and 34% in EDL. The data suggest that catecholamines secreted by the adrenal medulla exert an inhibitory control of Ca<jats:sup>2+<\/jats:sup>-dependent proteolysis in rat skeletal muscle, mediated by \u03b2<jats:sub>2<\/jats:sub>-adrenoceptors, with the participation of a cAMP-dependent pathway.<\/jats:p>","DOI":"10.1152\/ajpendo.2001.281.3.e449","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T17:46:39Z","timestamp":1513964799000},"page":"E449-E454","source":"Crossref","is-referenced-by-count":60,"title":["Catecholamines inhibit Ca<sup>2+<\/sup>-dependent proteolysis in rat skeletal muscle through \u03b2<sub>2<\/sub>-adrenoceptors and cAMP"],"prefix":"10.1152","volume":"281","author":[{"given":"Luiz Carlos C.","family":"Navegantes","sequence":"first","affiliation":[{"name":"Department of Physiology and Biochemistry, School of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, 14049 \u2013 900 S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neusa M. 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