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Insulin-induced glucose uptake, estimated by a 2-deoxyglucose technique, was increased 4- and 12-fold in control and food-restricted rats, respectively. Muscle insulin receptor was increased, but phosphotyrosine-associated phosphatidylinositol 3-kinase activity stimulated by insulin was lower in undernourished rats, whereas insulin receptor substrate-1 content remained unaltered. The main glucose transporter in the muscle, GLUT-4, was severely reduced albeit more efficiently translocated in response to insulin in food-deprived rats. GLUT-1, GLUT-3, and GLUT-5, minor isoforms in skeletal muscle, were found increased in food-deprived rats. The rise in these minor glucose carriers, as well as the improvement in GLUT-4 recruitment, is probably insufficient to account for the insulin-induced increase in the uptake of glucose in undernourished rats, thereby suggesting possible changes in other steps required for glucose metabolism.<\/jats:p>","DOI":"10.1152\/ajpendo.2001.281.5.e1101","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T19:57:52Z","timestamp":1513972672000},"page":"E1101-E1109","source":"Crossref","is-referenced-by-count":20,"title":["Glucose uptake and glucose transporter proteins in skeletal muscle from undernourished rats"],"prefix":"10.1152","volume":"281","author":[{"given":"Mar\u00eda","family":"Agote","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u0131\u0301mica, Centro Mixto Consejo Superior Investigaciones Cient\u0131\u0301ficas Universidad Complutense de Madrid, Facultad Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Goya","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u0131\u0301mica, Centro Mixto Consejo Superior Investigaciones Cient\u0131\u0301ficas Universidad Complutense de Madrid, Facultad Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ramos","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u0131\u0301mica, Centro Mixto Consejo Superior Investigaciones Cient\u0131\u0301ficas Universidad Complutense de Madrid, Facultad Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u0131\u0301mica, Centro Mixto Consejo Superior Investigaciones Cient\u0131\u0301ficas Universidad Complutense de Madrid, Facultad Farmacia, Universidad Complutense, Ciudad Universitaria, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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