{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:54:33Z","timestamp":1775984073096,"version":"3.50.1"},"reference-count":51,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Fatty acids (FAs) are acquired from free FA associated with albumin and lipoprotein triglyceride that is hydrolyzed by lipoprotein lipase (LpL). Hypertrophied hearts shift their substrate usage pattern to more glucose and less FA. However, FAs may still be an important source of energy in hypertrophied hearts. The aim of this study was to examine the importance of LpL-derived FAs in hypertensive hypertrophied hearts. We followed cardiac function and metabolic changes during 2 wk of angiotensin II (ANG II)-induced hypertension in control and heart-specific lipoprotein lipase knockout (hLpL0) mice. Glucose metabolism was increased in ANG II-treated control (control\/ANG II) hearts, raising it to the same level as hLpL0 hearts. FA uptake-related genes, CD36 and FATP1, were reduced in control\/ANG II hearts to levels found in hLpL0 hearts. ANG II did not alter these metabolic genes in hLpL0 mice. LpL activity was preserved, and mitochondrial FA oxidation-related genes were not altered in control\/ANG II hearts. In control\/ANG II hearts, triglyceride stores were consumed and reached the same levels as in hLpL0\/ANG II hearts. Intracellular ATP content was reduced only in hLpL0\/ANG II hearts. Both ANG II and deoxycorticosterone acetate-salt induced hypertension caused heart failure only in hLpL0 mice. Our data suggest that LpL activity is required for normal cardiac metabolic compensation to hypertensive stress.<\/jats:p>","DOI":"10.1152\/ajpendo.90338.2008","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T00:54:05Z","timestamp":1216774445000},"page":"E705-E713","source":"Crossref","is-referenced-by-count":24,"title":["Cardiac metabolic compensation to hypertension requires lipoprotein lipase"],"prefix":"10.1152","volume":"295","author":[{"given":"Haruyo","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyani G.","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira J.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7605"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603615103"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401028200"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509890200"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00298.2002"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104088"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213946"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Bishop SP, Altschuld RA.Increased glycolytic metabolism in cardiac hypertrophy and congestive failure.Am J Physiol218: 153\u2013159, 1970.","DOI":"10.1152\/ajplegacy.1970.218.1.153"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00281.2004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1994.1155"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(72)90213-5"},{"key":"R12","unstructured":"Crass MF, 3rd.Regulation of triglyceride metabolism in the isotopically prelabeled perfused heart.Fed Proc36: 1995\u20131999, 1977."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.265.3.E454"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Folch J, Lees M, Sloane Stanley GH.A simple method for the isolation and purification of total lipides from animal tissues.J Biol Chem226: 497\u2013509, 1957.","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Grynberg A, Demaison L.Fatty acid oxidation in the heart.J Cardiovasc Pharmacol28,Suppl1: S11\u2013S17, 1996.","DOI":"10.1097\/00005344-199606281-00003"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000137170.41939.d9"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.6.1064"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(73)90199-1"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(05)70040-0"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.6.2043"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.4.731"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034049.61181.F3"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.5.E958"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Mallov S, Alousi AA.Effect of altered cardiac metabolism and work on lipoprotein lipase activity of heart.Am J Physiol212: 1158\u20131164, 1967.","DOI":"10.1152\/ajplegacy.1967.212.5.1158"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1814"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R200015-JLR200"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01014.2005"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(83)90289-8"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.11.006"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04272.x"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(59)90172-9"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195102000-00002"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(68)90168-3"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(74)90248-6"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.06.004"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1007\/BF02544539"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2837"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"Saddik M, Lopaschuk GD.Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts.J Biol Chem266: 8162\u20138170, 1991.","DOI":"10.1016\/S0021-9258(18)92956-X"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00201-5"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015380609464"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Santalucia T, Camps M, Castello A, Munoz P, Nuel A, Testar X, Palacin M, Zorzano A.Developmental regulation of GLUT-1 (erythroid\/Hep G2) and GLUT-4 (muscle\/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue.Endocrinology130: 837\u2013846, 1992.","DOI":"10.1210\/endo.130.2.1370797"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1007\/BF01907926"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.20.2113"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.659235"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.5.416"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.014"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.2.304"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(86)90180-3"},{"key":"R50","doi-asserted-by":"crossref","unstructured":"Wick AN, Drury DR, Nakada HI, Wolfe JB.Localization of the primary metabolic block produced by 2-deoxyglucose.J Biol Chem224: 963\u2013969, 1957.","DOI":"10.1016\/S0021-9258(18)64988-9"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16751"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.90338.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T17:47:13Z","timestamp":1631555233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.90338.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1152\/ajpendo.90338.2008"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.90338.2008","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}