{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:28:19Z","timestamp":1759991299045},"reference-count":16,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p> Our hypothesis states that variceal pressure and wall tension increase dramatically during esophageal peristaltic contractions. This increase in pressure and wall tension is a natural consequence of the anatomy and physiology of the esophagus and of the esophageal venous plexus. The purpose of this study was to evaluate variceal hemodynamics during peristaltic contraction. A simultaneous ultrasound probe and manometry catheter was placed in the distal esophagus in nine patients with esophageal varices. Simultaneous esophageal luminal pressure and ultrasound images of varices were recorded during peristaltic contraction. Maximum variceal cross-sectional area and esophageal luminal pressures at which the varix flattened, closed, and opened were measured. The esophageal lumen pressure equals the intravariceal pressure at variceal flattening due to force balance laws. The mean flattening pressures (40.11 \u00b1 16.77 mmHg) were significantly higher than the mean opening pressures (11.56 \u00b1 25.56 mmHg) ( P \u2264 0.0001). Flattening pressures &gt;80 mmHg were generated during peristaltic contractions in 15.5% of the swallows. Variceal cross-sectional area increased a mean of 41% above baseline (range 7\u201389%, P &lt; 0.0001) during swallowing. The peak closing pressures in patients that experience future variceal bleeding were significantly higher than the peak closing pressures in patients that did not experience variceal bleeding ( P &lt; 0.04). Patients with a mean peak closing pressure &gt;61 mmHg were more likely to bleed. In this study, accuracy of predicting future variceal bleeding, based on these criteria, was 100%. Variceal models were developed, and it was demonstrated that during peristaltic contraction there was a significant increase in intravariceal pressure over baseline intravariceal pressure and that the peak intravariceal pressures were directly proportional to the resistance at the gastroesophageal junction. In conclusion, esophageal peristalsis in combination with high resistance to blood flow through the gastroesophageal junction leads to distension of the esophageal varices and an increase in intravariceal pressure and wall tension. <\/jats:p>","DOI":"10.1152\/ajpgi.00015.2004","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T23:58:07Z","timestamp":1094860687000},"page":"G830-G835","source":"Crossref","is-referenced-by-count":15,"title":["Mechanics and hemodynamics of esophageal varices during peristaltic contraction"],"prefix":"10.1152","volume":"287","author":[{"given":"Larry S.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothi","family":"Mekapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Izanec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sanderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Bohning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Desipio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasneet","family":"Gandegok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin J.","family":"Harberson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson","family":"Schneck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Nicosia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Thangada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beje","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elan","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Brasseur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060421"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90962-C"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.9.1162"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70233-6"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.2.8475273"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005541817491"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30177.x"},{"key":"R8","unstructured":"Miller LS. Non-invasive methods and apparatus for in vivo measurement of intra-variceal pressure and wall tension. U.S. Patent no. 5,878,749, March 9, 1999."},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07224.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90391-7"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240315"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80090-3"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70093-7"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Schiano TD, Adrain AL, Vega KJ, Liu JB, Black M, and Miller LS. High-resolution endoluminal sonography assessment of the hematocystic spots of esophageal varices. 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