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From ultrasound images, the esophageal cross-sectional area (CSA) at the peak of GER-induced distension was determined and compared between controls vs. patients, symptomatic vs. asymptomatic GER episodes, and before vs. during esomeprazole in GERD patients. The mean lumen CSA is greater in the patients than controls (271 \u00b1 71 mm<jats:sup>2<\/jats:sup> vs. 163 \u00b1 56 mm<jats:sup>2<\/jats:sup>, P = 0.001) but not different among asymptomatic reflux episodes, and those associated with regurgitation (290 \u00b1 110 mm<jats:sup>2<\/jats:sup>) or heartburn (271 \u00b1 67 mm<jats:sup>2<\/jats:sup>). Eight chest pain episodes associated with reflux revealed a tendency toward larger mean esophageal distension (459 \u00b1 40 mm<jats:sup>2<\/jats:sup>) compared with asymptomatic reflux (268 \u00b1 70 mm<jats:sup>2<\/jats:sup>, P = 0.058). Following esomeprazole treatment, most GER episodes were nonacidic and asymptomatic except in two patients in whom cyclical reflux was associated with large esophageal distensions. Esomeprazole did not alter the lumen CSA during GER. Esophageal distension is greater in the GERD subjects compared with controls; however, it is unlikely that the GER-induced distension of the esophagus plays a significant role in the genesis of heartburn sensation. Esomeprazole therapy does not alter the GER-induced distension of the esophagus. <\/jats:p>","DOI":"10.1152\/ajpgi.00019.2007","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T21:10:02Z","timestamp":1181250602000},"page":"G469-G474","source":"Crossref","is-referenced-by-count":22,"title":["Distension during gastroesophageal reflux: effects of acid inhibition and correlation with symptoms"],"prefix":"10.1152","volume":"293","author":[{"given":"Neelesh A.","family":"Tipnis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poong-Lyul","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder K.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.1.118"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Bernstein LM, Baker LA. 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