{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:57:34Z","timestamp":1771261054987,"version":"3.50.1"},"reference-count":24,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Kawasaki Foundation for Medical Science & Medical Welfare","award":["#27G-003"],"award-info":[{"award-number":["#27G-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p> Ultrasound tissue Doppler imaging (US-TDI) has been used to diagnose regional wall motion (WM) abnormalities in coronary artery disease but has not been applied to oropharyngeal diseases. This study aimed first to validate an US-TDI method to assess cervical esophageal (CE) WM and secondly to use the method to evaluate CE WM in patients with oropharyngeal dysphagia (OD). First, we enrolled 22 healthy men (mean age: 59.7 yr) who all underwent both US-TDI and videofluoroscopy (VF) and then esophageal high-resolution manometry (HRM) in the same week. We evaluated the reproducibility of the US-TDI and the relationship between US-TDI and other modalities (VF and HRM). Second, we enrolled 56 mild OD patients (mean age: 58.0 yr) and age- and sex-matched healthy controls. Difference in CE WM between these groups was evaluated by US-TDI. All healthy subjects underwent US-TDI, VF, and HRM successfully, with a sufficiently high reproducibility coefficient for this method, and significant correlation between US-TDI and VF\/HRM parameters. US-TDI showed mean time to open CE wall and mean velocity of CE wall opening significantly differed between patients and healthy controls ( P &lt; 0.01). In conclusion, we have developed a US-TDI method for easily assessing CE WM in daily practice and also found significant differences in CE WM between mild OD patients and healthy controls. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY A new ultrasonographic screening method using tissue Doppler imaging for oropharyngeal dysphagia was found to be a reliable, reproducible, and well-tolerated method. There is a significant correlation between this new method and conventional methods. This method revealed that patients having mild symptoms of oropharyngeal dysphagia had already significantly delayed cervical esophageal wall opening. <\/jats:p>","DOI":"10.1152\/ajpgi.00019.2017","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T00:20:48Z","timestamp":1504311648000},"page":"G32-G38","source":"Crossref","is-referenced-by-count":14,"title":["New ultrasonographic screening method for oropharyngeal dysphagia: tissue Doppler imaging"],"prefix":"10.1152","volume":"314","author":[{"given":"Noriaki","family":"Manabe","sequence":"first","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Nakato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine, Kawasaki Medical School General Medical Center, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8387"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/02699200500113996"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1109\/10.238473"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-001-0113-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-013-0026-x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90290-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3109\/00365521003592663"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.01.008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9696-8"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.08.007"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2000.19.1.15"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.3.1.1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/000331977903000803"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300753"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032014000300011"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817dfd02"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9712-z"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.685756"},{"key":"B20","unstructured":"U.S. Department of Health and Human Services. 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