{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:35:50Z","timestamp":1790055350286,"version":"4.0.1"},"reference-count":46,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p> Liver lymphocytes are enriched in natural killer (NK) cells, and activation of NK cells by injection of polyinosinic-polycytidylic acid (poly I:C) inhibits liver regeneration in the partial hepatectomy model via production of IFN-\u03b3. However, the role of NK cells in liver regeneration in a model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced liver injury remains unknown. In this study, we investigated the effect of activation of NK cells induced by poly I:C on liver regeneration in the CCl<jats:sub>4<\/jats:sub> model. Administration of poly I:C suppressed liver regeneration in CCl<jats:sub>4<\/jats:sub>-treated mice. Depletion of NK cells but not Kupffer cells or T cells restored liver regeneration in poly I:C\/CCl<jats:sub>4<\/jats:sub>-treated mice. Poly I:C and CCl<jats:sub>4<\/jats:sub> cotreatment synergistically induced accumulation of NK cells in the liver and NK cell production of IFN-\u03b3 and tumor necrosis factor (TNF)-\u03b1. Serum levels of these two cytokines were also synergistically induced after poly I:C and CCl<jats:sub>4<\/jats:sub> treatment. Finally, blockage of TNF-\u03b1 but not IFN-\u03b3 restored liver regeneration in poly I:C\/CCl<jats:sub>4<\/jats:sub>-treated mice. Taken together, these findings suggest that poly I:C treatment inhibits liver regeneration in the CCl<jats:sub>4<\/jats:sub>-induced liver injury model via induction of NK cell production of TNF-\u03b1. <\/jats:p>","DOI":"10.1152\/ajpgi.00026.2010","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T02:16:45Z","timestamp":1273198605000},"page":"G275-G282","source":"Crossref","is-referenced-by-count":17,"title":["Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via a tumor necrosis factor-\u03b1-dependent mechanism"],"prefix":"10.1152","volume":"299","author":[{"given":"Hairong","family":"Wei","sequence":"first","affiliation":[{"name":"Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 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